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Polymorphism of the μ opioid receptor gene (OPRM1) and visuotactile congruency effect

*. ***. ***. Congruent. Incongruent. Somatosensory. (Hz). 70. 30. 300ms. Congruent. Incongruent. Somatosensory. 12. 4. 600ms. Morphine. Polymorphism of the μ opioid receptor gene (OPRM1) and visuotactile congruency effect

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Polymorphism of the μ opioid receptor gene (OPRM1) and visuotactile congruency effect

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  1. * *** *** Congruent Incongruent Somatosensory (Hz) 70 30 300ms Congruent Incongruent Somatosensory 12 4 600ms Morphine Polymorphism of the μopioid receptor gene(OPRM1) and visuotactile congruency effect Noriaki Kanayama Masahiro Matsunaga Hideki OhiraThe University of Tokyo Fujita Health University Nagoya University μopioid receptor gene VisuoTactile Congruency Effect The analgesic (pain relieving) effects due to decreased perception of pain by increased pain tolerance Congruent Gamma Incongruent Polymorphism related to sensory threshold Theta The SNP in the μ opioid receptor gene (OPRM1) 118A>Ghigh endogenous opioid tone -> decreased response to nociceptive stimulation (Martin et al., 2003 for opioid receptor knockout Mice) Somatosensory Visuotactile Stimulation Reaction Time Results EEG oscillatory activities in gamma and theta band 118A>G -> decreased N1 (ERP) response to nociceptive stimulation (Lötsch et al., 2006 for human) Gamma and Theta Theory for Visuotactile Integration process Gamma band oscillation reflects the crossmodal binding process, while theta band oscillation reflects the conflict resolution of visuotactile spatial incongruence. The possibility that the SNP modulates the threshold of sensory perception Kanayama et al., 2009 Neuroreport Methods Participants: 14 right-handed undergraduates AA: 2 female/ 2 male AG: 3 female/ 1 male GG: 3 female/ 3 male A carriers: 5 female/ 3 male A non-carriers: 3 female/ 3 male Design: Congruency (Congruent, Incongruent, Somatosensory) as a within-participants factorOPRM Polymorphism (A carrier, A non-carrier) as a between-participants factor Measure: Congruency Effect on RTEEG (32 elecs, SR: 500Hz, nose-tip reference, 0.1-120Hz band pass filter) VisuoTactile Congruency Task The temporal sequence of 1 trial 120 trials (40 trials x 3 condition) x 2 blocks Results AA+AG GG GG AA+AG 5 3 CON CON INC INC -5 -3 SD SD SOM SOM ms 600ms Reaction Times 300ms Gamma band (30-60 Hz) activities Theta band (4-7 Hz) activities * The group differences between 118A non-carrier (GG) and118A carrier (AA+AG) individuals Overall congruency effect : 118A non-carrier (GG) individuals < 118A carrier (AA+AG) individuals Theta band response in the later time course (300-500ms, peak values): 118A non-carrier (GG) individuals < 118A carrier (AA+AG) individuals Incongruent > Congruent Incongruent > Somatosensory p < .05 p < .01 ms p < .01 only in 118A carrier (AA+AG) individuals p < .01 Visuotactile CongruencyEffects on RT Discussion μopioid receptor is a modulating factor on the visuotactile integration process The polymorphism of μ opioid receptor gene, which is considered as a analgesic effects or a decreased pain perception, also has an impact on the visuotactile integration process. This suggests that the integration or cognition of the sensory inputs (not limited to pain perception) are modulated the OPRM1 as a congenital individual difference. The effect of the OPRM1 on the visuotactile integration process mainly stems from the difference of conflict resolution process.

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