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DERMABOND ® Topical Skin Adhesive

DERMABOND ® Topical Skin Adhesive. The Final Layer of Protection. DERMABOND ® Adhesive is equivalent to other commercially available skin closure devices, studied effectively from small to long incisions up to 69cm. What is DERMABOND Topical Skin Adhesive?.

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DERMABOND ® Topical Skin Adhesive

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  1. DERMABOND® Topical Skin Adhesive • The Final Layer of Protection

  2. DERMABOND® Adhesive is equivalent to other commercially available skin closure devices, studied effectively from small to long incisions up to 69cm.

  3. What is DERMABOND Topical Skin Adhesive? Cyanoacrylates were developed in 1949 1970s - n-butyl-2-cyanoacrylate 1999 - 2-Octyl-Cyanoacrylate (DERMABOND) 1st FDA approved Topical Skin Adhesive Today – over 5 million patients a year are treated with DERMABOND Adhesive DERMABOND Adhesive is a unique technology • 2 Octyl cyanoacrylate has the longest carbon side chain for increased flexibility and, increased breaking strength versus butyl cyanoacrylate1 • In vivo and In vitro studies demonstrate a proven microbial barrier against bacteria which may cause infection. • 24 months shelf life, stores at room temperature • a violet, non tattooing dye for easy observation 1. Quinn, JV Tissue Adhesives in Wound Care, BC Decker 1998. Attached are chapters from the book.

  4. OCA: 300-500 microns thick compared to other N- Butyls at : <50 microns thick Mechanism of action is a combination of monomer and plasticizers, that polymerizes to form a flexible/pliable adhesive film • Sets or cures within 45-90 seconds following final layer • Reaches full mechanical strength in 1 min • If needed, can be wiped from skin within 10 seconds after application or with a petroleum based product after setting • Adhesive film sloughs or falls off wound within 7-10 days as skin re-epithelialize • Equivalent to 7 days wound healing strength in 3 minutes1 • 1. Singer and Hollander, Lacerations in Acute Wounds: An evidence-based guide, p.85 2. DERMABOND adhesive package insert 3

  5. DERMBOND Adhesive has proven strength over n-butyls and n-butyl blends due to it’s unique formulation. This strength is critical for topical wound closure and microbial barrier. Wound Bursting Strength Compliance Analysis

  6. In vivo studies demonstrated DERMABOND Adhesive microbial barrier provides greater protection than sutures alone as well as n-butyls/ n-butyl blend adhesives.

  7. DERMABOND® Adhesive has unique benefits that offer the potential to impact the cost of care. *Health and Economic Outcomes after OB-GYN Surgery: A Comparison of Skin Closure Techniques Susan G. Murrmann, MD1, Jeffrey S. Markowitz, DrPH2, Elane M. Gutterman, PhD2, Glenn Magee, MBA3 1 University of Tennessee, Department of Obstetrics & Gynecology, Memphis, TN 2 Health Data Analytics, Princeton Junction, NJ 3 Ethicon Inc., Somerville, NJ *Poster Presentation at 2008 Annual Clinical Meeting of The American College of Obstetricians and Gynecologists, New Orleans, LA, May 3-7, 2008

  8. DERMABOND Adhesive for final skin closure provides benefits for surgeons, nurses, patients, and hospitals. Physician, Hospital -centered Benefits Proven microbial barrier for lasting protection 7 days of wound healing strength in 1 minutes for strong closure and peace of mind No time spent removing staples or sutures Reduces needle stick exposure Increases patient satisfaction Reduced Hospitalization Costs • Nurse, Patient -centered Benefits • Reduces number of suture set ups • Ease of Post Op wound checks • Reduces number of wound dressings • Shower immediately • Excellent Cosmesis Scott GR, Carson, CL, Borah, GL, DERMABOND skin closures for bilaterial reduction mammoplasties: a review of 255 consecutive cases. Plast Reconst Surg.2007;120:1460-1465.

  9. Things to consider for successful outcomes Standard wound management Remove surgical prep solution Ensure hemostasis Precise application technique Thin layers Dry before bandage No petroleum-based products over DERMABOND Adhesive Post surgical ChloraPrep wipe downs ok as long as DERMABOND Adhesive has dried and the area is not vigorously scrubbed

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