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Role of Rho-A in Glaucoma

Role of Rho-A in Glaucoma. Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli. Outline. Open angle Glaucoma RhoA pathway and hypothesis CATPA. Open Angle Glaucoma. It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP). Anatomy of the angle.

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Role of Rho-A in Glaucoma

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  1. Role of Rho-A in Glaucoma Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli

  2. Outline • Open angle Glaucoma • RhoA pathway and hypothesis • CATPA

  3. Open Angle Glaucoma It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP)

  4. Anatomy of the angle

  5. Trabecular meshwork Cornea Retina Shields textbook of glaucoma-2005

  6. Cell cytoskeleton Green: actin Red: mitochondria Blue: nucleus

  7. TM Cell Contractility • Aqueous humor regulation is done by TM cell contractility and re-alignment of pores. • There are two pathways that regulate TM contractility. • Ca dependent pathways • And the Ca independent pathway. • Rho-a protein is involved in the Ca independent pathway.

  8. General Function of Rho-A • Involved in the maintenance of tight junctions. • Tight junctions are found in epithelial cells and all cells where there is a separation or demarcation into different regions. • If the Rho-A pathway does not function properly in the eye, it causes Glaucoma.

  9. pMLC Ca independent pathway MLC Relaxation Contraction Inactive MLCP Active MLCP PP1Cd PP1Cd M20 M20 MYPT1 MYPT1 Plasma membrane P GAP RhoA-GDP RhoA-GTP Rhokinase GEF RhoA-GDP GTP GDP GDI

  10. CATPA

  11. CATPA

  12. Point Mutations

  13. Point Mutations

  14. References • 1. http://biology.kenyon.edu/BMB/Chime2/ 2002/rhoA/FRAMES/captxt.htm • 2. http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=165390 • 3. PDB, CATH, SCOP • 4. http://ajpcell.physiology.org/cgi/content/full/275/3/C798 • 5.http: //www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1220893 • 6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14815 • 7. http://147.52.72.117/ijmm/2002/volume9/number6/563-570.pdf • 8. http://apodaca2.dept-med.pitt.edu/PDFs/Rajasesekeran-TJs.pdf • 9. www.ucl.ac.uk/ioo/research/greenwood.htm

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