Strabismus, Amblyopia & Leukocoria

1. Strabismus, Amblyopia & Leukocoria Dr. Hessah Alodan, Pediatric Opthalmology Dept, KAUH

2. Why Two Eyes ? You can demonstrate to a patient the difference in their field or their child's field with one eye compared to two. With two eyes you can also demonstrate the peripheral field and the central fusion.

3. Why Two Eyes ? Left Eye Monocular   Right Eye Monocular   Binocular   Total binocular field is nearly 170 degrees (varies according to configuration of orbits)

4. Why Two Eyes ? Two Pencils Test The same person with one eye closed or with manifest strabismus or no stereopsis will miss the examiner's pencil initially and place it correctly only after the second or third try. With both eyes open the patient who uses both eyes producing stereopsis can put his pencil accurately on the examiner's pencil if stereopsis is present

5. Visual Axis • Imaginary line between fovea and the object • Binocular Vision • If the visual axises from both eyes intersect at the object, binocular vision occurs

6. Sensory Fusion • Supper imposed images from each corresponding retinal area in binocular cells at the level of the occipital cortex • Same images • Similar in size • Similar in clarity • Motor Fusion • Ability to physically move the eyes so that they are pointing in the same direction allowing the corresponding areas of the retina in each eye to be pointing at the object of regard

7. Visual Axes Misalignment lead to: • Confusion • Superimposition of the two different images stimulating corresponding retinal points • Diplopia • One object stimulating two none corresponding retinal points

8. Compensatory mechanism to misalignment of VA : • Suppression • Subconscious active neglect of one eye input that occurs only when both eyes are open • Amblyopia

9. Action of extraocular muscles

10. What is Strabismus ? Ocular misalignment due to abnormality in binocular vision or anomalies in neuromuscular control of ocular motility

11. Classification of Strabismus: • According to fusion status • Phoria • Latent tendency of the eye to deviate and controlled by fusional mechanism • Intermittent Phoria • Fusion control is present part of the time • Tropia • Manifest misalignment of the eye all the time

12. Classification of Strabismus: • According to fixation • Alternating • Spontaneous alternation of fixation from one eye to the other • Monocular • Preference of fixation with one eye

13. Classification of Strabismus: • According to type of deviation • Horizontal • Esodeviation • Exodeviation • Vertical • Hyperdeviation • Hypodeviation • Torsional • Incyclodeviation • Excyclodeviation • Combined

14. Classification of Strabismus: • According to age of onset • Congenital • Acquired

15. Classification of Strabismus: • According to variation of the deviation with gaze position or fixing eye • Comitant • Same deviation in different direction of gaze • Incomitant • Variable deviation in different direction of gaze usually in paralytic or restrictive type of strabismus

16. Examination • History • Inspection • Assessment of monocular eye function • Visual acuity • Preverbal children • CSM • OKN • Preferential looking • Visual evoked potential

17. Examination • Assessment of monocular eye function • Visual acuity • Verbal children • Symbol tests • Single illiterate E • Allen pictures • H O T V letters

18. Examination • Assessment of binocular eye function • Hirschberg test • Krimski’s test • Cover test • Alternate cover test • Prism cover test

19. Examination • Fundoscopy • Cycloplegic refraction • Tropicamide • Cyclopentolate • Atropin

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34. Type of Strabismus • Esotropia • Pseudoesotopia • Infantile esotropia • Accommodative esotropia • Partially accommodative esotropia

35. Pseudoesotropia • Occur in patients with flat broad nasal bridge and prominent epicanthal fold • Gradually disappear with age • Hirschberg test differentiate it from true esotropia

36. Infantile Esotropia • Common comitant esotropia occur before six month of age • Deviation is often large more than 40 prism diopter • Frequently associated with nystagmus and inferior oblique over action • Treatment • Correction of refractive error • Treat amblyopia • Surgical correction of strabismus

37. Accommodative Esotropia • Occur around 2 ½ years of age • Start as intermittent then become constant • High hypermetropia • Treatment • Full cycloplegic correction • Treat amblyopia

38. Partially Accommodative Esotropia • Improve partially with glasses • Treatment • Full cycloplegic correction • Treat amblyopia • Surgical correction of strabismus

39. Type of Strabismus • Exotropia • Intermittent exotropia • Constant exotropia • Sensory exotropia

40. Intermittent exotropia • Onset of deviation within the first year of age • Closing one eye in bright light • Usually not associated with any refractive error • Usually not associated with amblyopia • Treatment • Correction of any refractive error • Surgical correction of strabismus

41. Constant exotropia • Maybe present at birth or maybe progress from intermittent exotropia • Treatment • Correction of any refractive error • Correction of amblyopia • Surgical correction of strabismus

42. Sensory exotropia • Constant exotropia that occur following loss of vision in one eye e.g trauma • Treatment • Correction of any organic lesion of the eye • Correction of amblyopia • Surgical correction of strabismus

43. Types of Strabismus • Paralytic strabismus • 6th nerve palsy • 4th nerve palsy • 3rd nerve palsy

44. 6th Nerve Palsy • Incomitant esotropia • Limitation of abduction • Abnormal head position

45. 4th Nerve Palsy • Congenital or acquired • Hypertropia of the affected eye with excyclotropia • Abnormal head position

46. 3rd Nerve Palsy • Congenital or acquired • Exotropia with Hypotropia of the affected eye • In children caused by: trauma, inflammation, post viral and tumor • In adult caused by: aneurysm, diabetes, neuritis, trauma, infection and tumor

47. Special Types of Strabismus • Duane strabismus • Brown syndrome • Thyroid opthalmopathy

48. Duane Syndrome • Limitation of abduction • Mild limitation of adduction • Retraction of the globe and narrowing of the palpebral fissure on adduction • Upshoot or downshoot on adduction • Pathology faulty innervation of the lateral rectus muscle by fibers from medial rectus leading to co-contraction of the medial rectus and lateral rectus muscles

49. Brown Syndrome • Limitation of elevation on adduction • Restriction of the sheath of the superior oblique tendon • Treatment needed in abnormal head position or vertical deviation in primary position

50. Thyroid Ophthalmopathy • Restrictive myopathy commonly involving inferior rectus, medial rectus and superior rectus • Patients presents with hypotropia, esotropia or both