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Comparative Effectiveness Research Key Function Committee (CER KFC) Monday, July 16 2012, 11:00 AM-12:00 PM ET

Comparative Effectiveness Research Key Function Committee (CER KFC) Monday, July 16 2012, 11:00 AM-12:00 PM ET. Co-Chairs, Tim Carey and Tom Concannon PI Liaison, Harry Selker NIH Coordinator, Rosemarie Filart PM, Colleen Lawrence (C4).

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Comparative Effectiveness Research Key Function Committee (CER KFC) Monday, July 16 2012, 11:00 AM-12:00 PM ET

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  1. Comparative Effectiveness ResearchKey Function Committee(CER KFC)Monday, July 16 2012, 11:00 AM-12:00 PM ET Co-Chairs, Tim Carey and Tom Concannon PI Liaison, Harry Selker NIH Coordinator, Rosemarie Filart PM, Colleen Lawrence (C4)

  2. CTSA CER Key Function Committee (KFC) Monthly Meeting AgendaMonday, July 16, 2012, 11:00 AM – 12:00 PM ETTeleconference Only Dial-in: 1 877 568 4109 Access Code: 271-247-588Go To Meeting Registration (only) link https://student.gototraining.com/r/1271356837225888256

  3. All Members invited to participate in any group

  4. New CTSA FOA: RFA-TR-12-006, released and July 23rd webinar https://ncatsevents.webex.com/ncatsevents/onstage/g.php?t=a&d=660437516 Date: Monday, July 23, 2012 Time: 2:00-3:30 PM EDT Questions: CTSAFOAQuestions@mail.nih.govIdentify current activities and collaborations with CER KFC members with NIH I/CsUpdate Summary of Representatives from other entities NIH Updates Rosemarie Filart 11:02 AM

  5. Representation from Federal entities, CTSA Affiliates, and other Stakeholders

  6. PCTi WorkshopPlanning Committee - DRAFT Schedule for Use Case Development and Selection • July-August: Proposed “Use Case” identification and development • KFCs members and stakeholders nominate proposed use cases • Planning Committee works with nominators to develop proposed use cases • Methods, CE, PBRN, Informatics, Evaluation, DIR, and other workgroups identify infrastructure capacity and needs of proposed use cases • September: “Use Case” selection (Planning Committee) • ~4 use cases will be selected to provide learning ground for the CTSA community about PCT infrastructure • September-November: Continued “Use Case” development • November 19: PCTi Workshop • 2012 – 2014: PCT development • Leadership by CTSAs, investigators and stakeholders

  7. The FuRTHeR Platform CER SCIENTIFIC PRESENTATION Presented by: Ram Gouripeddi, MD, MSUniversity of Utah11:08AM

  8. FURTHeR: A Comparative Effectiveness Research Infrastructure for PHIS+ Joyce Mitchell, PhD & Ram Gouripeddi, MD, MS Department of Biomedical Informatics, University of Utah Monday, July 16th, 2012

  9. Conflict-of-Interest Statement We declare no conflicts of interests related to the work being presented here.

  10. Acknowledgements • FURTHeR development was supported by the NCRR and the NCATS, NIH, through Grant UL1RR025764 and supplement 3UL1RR025764-02S2. This project was funded under grant number R01 HS019862-01 from the AHRQ, U.S. Department of Health and Human Services (HHS). The opinions expressed [in this document] are those of the authors and do not reflect the official position of AHRQ or the HHS. • PHIS+ Team members across multiple institutions • FURTHeR Team members

  11. Original Purpose of FURTHeR • Support clinical and translational research • Join data from multiple sources for retrospective studies • Current state: Support pre-research questions for feasibility analysis across four data sources. [UUEDW, IHEDW, UPDB, Biospecimens]

  12. Clinical Genotypic Phenotypic Public health Other Partners Genealogic The FURTHeR CCTS Mission Univ of Utah Hospitals & Clinics FURTHeR=Federated Utah Research & Translational Health e-Repository Huntsman Cancer Institute Intermountain Healthcare VAMC Salt Lake City UDOH

  13. FURTHeR Components • Terminology/Ontology Server • Metadata Repository • Federated Query Engine • Data Source Adapters • Query Tool • Admin & Security Components

  14. FURTHeR as a CER Infrastructure

  15. Technologies Schultz et. al, An Overview of Architecture and Technologies Used from Query to Data Source

  16. PHIS+ • Agency for Healthcare Research and Quality (AHRQ) PROSPECT funded project. • Augment the Children’s Hospital Association’s (CHA) (formerly Child Health Corporation of America) existing electronic database of detailed administrative data - the Pediatric Health Information System (PHIS) with clinical data to conduct Comparative Effectiveness Research studies. • UU BMI - Informatics Partners PHIS+ PHIS UU BMI

  17. PHIS+ Overview

  18. The PHIS+ Process 6 2 4 3 5 1

  19. PHIS+ Project Organizational Structure Raj Srivastava, MD, MPH UU, PI Joyce Mitchell, PhD UU, Informatics PI Ram Gouripeddi, MD, MS Research Associate Phillip Warner Software Engineer Peter Mo Data Architect Ryan Butcher Terminologist Rick Bradshaw Data Architect Matt Whittaker Informatics Project Manager

  20. Electronic Data Sources for PHIS+ Hospitals Narus et. al, Federating Clinical Data from Six Pediatric Hospitals: Process and Initial Results from the PHIS+ Consortium. AMIA 2011

  21. Developmental Process Overview Narus et. al, Federating Clinical Data from Six Pediatric Hospitals: Process and Initial Results from the PHIS+ Consortium. AMIA 2011

  22. Lab Data Model

  23. Microbiology Data 1 1 * 1 * Specimen Culture Patient 0..* 1 0..* Micro-organism Anti-microbial Susceptibility

  24. PHIS+ Microbiology Model Harmonized Data Model PHIS+ Micro Data Model

  25. PHIS+ Microbiology Model

  26. Radiology Data Model Free Text Fields

  27. Integrating NLP Extracts Clinical Research Criteria Data FURTHeR Data for CER Study Structured Clinical Data Corpora Export based on Clinical Research Criteria NLP: Annotation & Information Extraction

  28. PHIS+ CER Database

  29. Metadata & Data Quality Ask sites to provide a metadata file for each load. Analyze the metadata file with what is currently available in the DTS server for that site. No Processing Complete. Yes

  30. In Summary

  31. References • Gouripeddi R, Mitchel JA, Narus SP et al. Federating Clinical Data from Six Pediatric Hospitals: Process and Initial Results for Microbiology from the PHIS+ Consortium AMIA AnnuSymp Proc. 2012 (Accepted). • Narus SP, Srivastava R, Gouripeddi R, et al. Federating Clinical Data from Six Pediatric Hospitals: Process and Initial Results from the PHIS+ Consortium. AMIA AnnuSymp Proc. 2011;2011:994–1003. • Bradshaw RL, Matney S, Livne OE, et al. Architecture of a Federated Query Engine for Heterogeneous Resources. AMIA AnnuSymp Proc. 2009;2009:70–74. • Livne OE, Schultz ND, Narus SP. Federated Querying Architecture with Clinical & Translational Health IT Application. Journal of Medical Systems. 2011;35(5):1211–1224. • Matney S, Bradshaw RL, Livne OE, et al. Developing a Semantic Framework for Clinical and Translational Research. 2011 AMIA Summit on Translational Bioinformatics. Available at: http://proceedings.amia.org/16pc81/. • Website: http://further.utah.edu/index.xhtml

  32. THANK YOU

  33. UPCOMING CER SCIENTIFIC PRESENTATIONCentral Indiana Innovation Network (CI-Net)August 20thPresented by: micHaelmurray, Pharmd, MPHIndiana University School of MedicineWELCOME VOLUNTEERS or SUGGESTIONS

  34. WORKGROUP REPORTS11:16AM

  35. DIR Workgroup co-Leads: Paul Meissner and Jonathan Tobin October 2011 Fall –Winter 2011 2012 • Merged Collaboration and Dissemination and Implementation Workgroups launched into one WG: newly named as Dissemination and Implementation Research WG • White Paper on Stakeholder Engagement • - Working paper on CTSA wiki • - Submitted for peer review • 2. Best Practices in Translational Research • 7 interviews completed • Developed preliminary results • 15 interviews proposed & scheduled • Identification of variables of interest for D&I research from EHRs and other data sources. • 1. White Paper on Stakeholder Engagement – published JGIM May 2012 • 2. CTSA Structured Interviews Dissemination Research –interviews completed, summary presented, presentations and manuscript on best practices in progress • 3. Stakeholder engagement demonstrations • Tufts EPC (5) • PPP KFC (1) • Other • Variables of interest for D&I research – link with NCI GEM initiative • 4. Rapid D&I Network / Pilot DIR demonstrations • - Needs leadership Completed To be Completed

  36. Methods Workgroupco-Leads: Sean Tunis , Mark Helfand, Jerry Krishnan and Peter Neumann October 2011- Jan 2012 Feb 2012-October 2012 June – October 2011 Fall 2012 Develop and conduct an Methods WG Mini-Workshop of the October 2011 CER KFC Annual meeting with stakeholders. Focus on specific ways to advance methods research as detailed in the forthcoming CER Methods Agenda Paper. Discuss WG projects in light of the current CER/PCOR environment. • Dec 2011– Jan 2012:   • Key informant interviews on current consortium efforts to expand national infrastructure for conducting community-based PCTs • Jan 2012: Compile findings from key informant interviews Feb-May 2012: Create prioritized list of projects/ topics for discussion at CTSA PCTi workshop. Establish a planning committee with CER and CE KFC workgroup leaders. October 2012: Workshop to convene individuals and groups from CTSA program and other initiatives with shared interest in expanding national infrastructure for community-based PCTs • Fall 2012:   Produce white paper with strategic plans for CTSA CER methods workgroup to contribute to expansion of national infrastructure for community based PCTs (CTSA PCTi) Completed To be Completed

  37. CER Informatics TaskforceOpen Discussion:*Projects*In-person CER KFC Informatics Taskforce meeting with the CER KFCCo-Leads: Joel Saltz and Bill Hersh

  38. LIAISON REPORTS11:40AM

  39. Liaison Member Reports

  40. Membership Updates, Ideas, Suggestions, and NewsALL11:50AM

  41. C4 UpdatesColleen Lawrence, CER PM11:58 AM

  42. CER KFC Monthly Meeting: Monday, August 20th from 11 AM-12PM Capacity and Needs Assessment Workgroup: Monday, July 16th from 4-5 PM EDT Dissemination and Implementation Research Workgroup: Tuesday, July 17th from 4-5 PM EDT Methods Workgroup: Thursday, July 26th from 12-1 PM EDT Informatics Taskforce: Thursday, August 2nd from 12 - 1 PM EDT Operations Group: Tuesday, July 24th3-4 PM EDT *attended by Co-Chairs /WG-TF Leads/ KFC Coordinator/PI Liaison SGC #4 Bi-Monthly Meeting : Monday, July 23rdfrom 11 AM- 12 PM EDT *attended by CER and Comm. Eng. KFC Co-Chairs /WG-TF Leads/ KFC Coordinator/PI Liaison CER KFC Upcoming meeting schedule

  43. APPENDIX (Proceed If needed)

  44. CTSA Consortium Executive Committee Three Objectives for SGC #4 Objective 1: (Recognized as the Priority Objective by CCEC) :Develop a CTSA Consortium-wide strategy for community-engaged and comparative effectiveness research that leads to improvements in the access, quality, and efficiency of healthcare delivery and the health of diverse communities and the public. (*Metric followed by CCEC). Objective 2: Collaborate and create synergies with a wide range of stakeholders (i.e., communities, health departments, CTSA and other academic medical centers, NIH Institutes and Centers and other DHHS Federal Partners) in planning and implementing community-engaged and comparative effectiveness research and in disseminating the research findings. Objective 3: Facilitate collaborations across CTSA institutions, PBRNs, and a broad cross-section of practice settings that increase the nation’s capacity for innovative community-engaged and comparative effectiveness research leading to the development of novel methodologies for both conducting research and for implementing and disseminating the findings of that research.

  45. Mission Statement The Comparative Effectiveness Research (CER) Key Function Committee builds the field of comparative effectiveness research (CER) and patient-centered outcomes research by creating a learning community across CTSA institutions, spurring the development of methods, expanding training and education, promoting community and public engagement, applying CER findings and sharing successes and lessons learned. Vision Statement Through collaborative work products, the Comparative Effectiveness Research (CER) Key Function Committee facilitates the generation and synthesis of evidence about alternative interventions that results in actionable findings for policymakers, clinicians, patients, and purchasers to use in improving the quality and outcomes of patient-centered health care. CER KFC Mission and Vision Statements https://www.ctsawiki.org/wiki/display/CER/Comparative+Effectiveness+Research-+Home

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