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TUMORACIÓN MAMARIA

TUMORACIÓN MAMARIA. B. Ocaña Castillo; A. Martínez Torrano; P. Blasco Muñoz; F. Martínez Díaz; F. Pastor Quirante; G. Ortuño Pacheco (H.G.U. Reina Sofía, Murcia) . HISTORIA CLÍNICA. Mujer 86 años

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TUMORACIÓN MAMARIA

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  1. TUMORACIÓN MAMARIA B. Ocaña Castillo; A. Martínez Torrano; P. Blasco Muñoz; F. Martínez Díaz; F. Pastor Quirante; G. Ortuño Pacheco (H.G.U. Reina Sofía, Murcia)

  2. HISTORIA CLÍNICA • Mujer 86 años • AP: HTA; insuficiencia cardiaca; 2 cateterismos; 3 stent; insuficiencia renal; ooforectomizada; operada de glaucoma y cataratas • Enfermedad actual: tumoración mamaria (CSE) de 6cm de 1 año de evolución que crece progresivamente

  3. citoqueratina

  4. DIAGNÓSTICO METÁSTASIS DE MELANOMA

  5. TUMORES METASTÁSICOS EN LA MAMA • Mtx a mama desde tumores extramamarios raras • Infancia: RMS embrionario • Adultos: leucemia/linfoma/MM/carcinoma • Incidencia: 2% • 40% primera manifestación

  6. Nódulos solitarios, CSE, superficiales. Gg axilares + (25-80%). Unilaterales • Pruebas de imagen: circunscritas, no calcificadas. Av indistinguibles de 1º mama • Localización 1º: PTS Y MMSS (vía linfática) • Impt buena correlación cx-rx y sospecha: aspecto inusual para 1º mama/ausencia componente in situ/características típicas de o: primario: pigmento/ inclusiones intranucleares) • IHQ: S-100 (S:> 95%). CA mama 60% HMB-45 y Melan A: S: 70% Citoqueratinas – (av expresión aberrante de CAM5.5 y EMA)

  7. Tto y evolución diferente • Muerte 1º año desde dco • Pronóstico dep de sitio 1º y tipo histológico

  8. BIBLIOGRAFIA • O´malley FP, Pinder SE. Metastasic Tumors in “Breast Pathology”. Foundations in Diagnostic Pathology Series. Churchill Livingstone. Elsevier. China 2006. Pp 297-301, 311. • Tavassoli Fa, Devillee P (Eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press: Lyon 2003.Pags. 109;112 • Smyrniotis V, Theodosopoulos Th, Marinis A, Goula K, • Pshychogios J, Kondi-Pafiti a. Metastastic Disease in the • Breast From Nonmammary Neoplasm. Eur Gynaecol • Oncol.2005;26(5):547-50.

  9. •Noguera JJ, Martinez-Miravete R, Idoate F, Diaz L,Pina L,Zornoza G. Metastasis to the Breast: a Review of 33 Cases.Australasian Radiology 2007;51:133-138. •Lee AHS.The Histological Diagnosis of Metastases to thebreast from xtramammary Malignancies. J Clin Pathol2007; 60:1333-1341. • •Loffeld A. Marsden JR.Management of Melanoma • Metastasis to the Breast: Case Series and Review of theLiterature. Br J Dermat 2005; 152:1206-1210.

  10. •Loffeld A. Marsden JR.Management of Melanoma Metastasis to the Breast: Case Series and Review of the Literature. Br J Dermat 2005; 152:1206-1210. •Kurul S,Tas F, Büyükbabani N, Mudum A, Baykal C, Camlica H. Different Manifestations of Malignant Melanoma in the Breast:A Report of 12 Cases and a Review of theLiterature.Jpn J Clin Oncol 2005;35 (4): 202-206.

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