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UDP-NAcMur- L-Ala

L-Ala. MurC. UDP-NAc-Mur. UDP-NAcMur- L-Ala. NADP +. D-Glu. ATP. ADP + P i. ATP. Mur B. MurD. NAD P H + H +. ADP + P i. UDP-NAcGlc-EP. UDP-NAcMur- L-Ala-D-Glu. Cytoplasmic step. meso -A2pm or L-Lys. P i. ATP. Mur A. MurE. P EP. ADP + P i.

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UDP-NAcMur- L-Ala

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  1. L-Ala MurC UDP-NAc-Mur UDP-NAcMur-L-Ala NADP+ D-Glu ATP ADP + Pi ATP MurB MurD NADPH + H+ ADP + Pi UDP-NAcGlc-EP UDP-NAcMur-L-Ala-D-Glu Cytoplasmic step meso-A2pm or L-Lys Pi ATP MurA MurE PEP ADP + Pi UDP-NAcMur-L-Ala-D-Glu-mA2pm UDP-NAcGlc ATP Ddl 2 D-Ala D-Ala-D-Ala ADP + Pi MurF UDP-NAcMur pentapeptide undecaprenyl-P MraY UMP Nac-Mur pentapeptide pyrophosphoryl undecaprenol (lipid I) Membrane step UDP-Nac-Glc MurG UDP Nac-Glc-Nac-Mur pentapeptide pyrophosphoryl undecaprenol (lipid II) Periplasmic step transglycosylationtranspeptidation PBPs CH2OH CH2OH CH2OH CH2OH CH2OH CH2OH O O O O O O HO O O O O O OH O OH O OH O OH CH3CH NHAc CH3CH NHAc CH3CH NHAc NHAc NHAc NHAc CO CO CO Ala Ala Ala Gln Gln Gln Ala mA2pm mA2pm mA2pm Ala Ala Ala Ala Ala Ala mA2pm mA2pm mA2pm Ala Gln Gln Gln Ala Ala Ala CO CO CO CH3CH CH3CH CH3CH CH2OH CH2OH CH2OH CH2OH CH2OH CH2OH O O O O O O HO O O O O O OH O OH O OH O OH NHAc NHAc NHAc NHAc NHAc NHAc

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