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Innate Immunity: Signaling via Toll-Like Receptors in Reactome

Innate Immunity: Signaling via Toll-Like Receptors in Reactome. Peter D’Eustachio June 11, 2012. Data model in a nutshell. Regulation. Input 1. Output 1. protein ( UniProt ) or m molecule ( ChEBI ) or complex ( GO/PRO ). Reaction. Input 2. Output 2. CatalystActivity

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Innate Immunity: Signaling via Toll-Like Receptors in Reactome

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  1. Innate Immunity: Signaling via Toll-Like Receptors in Reactome Peter D’Eustachio June 11, 2012

  2. Data model in a nutshell Regulation Input 1 Output 1 protein (UniProt) or mmolecule (ChEBI) or complex (GO/PRO) Reaction Input 2 Output 2 CatalystActivity (GO mol function) location (GO cell component) Pathway (GO biol process) Pathway Reaction Reaction

  3. Data model details: working form of a protein, complex

  4. Web site home page (www.reactome.org)

  5. Divide reaction space into ~160 “canonical pathways”, each represented by an SBGN-like diagram

  6. Event hierarchy for Toll-like receptor signaling

  7. Early events in TLR4 signaling – details of a complex

  8. TLR4 signaling – functional interactors of CD14

  9. Functional interactors link TLR signaling pathways

  10. Credits OICR / CSHL Lincoln Stein Michael Caudy Marc Gillespie Robin Haw Bruce May Marija Orlic-Milacic Karen Rothfels Joel Weiser Guanming Wu EBI Henning Hermjakob Ewan Birney David Croft Antonio Fabregat-Mundo Phani Garapati Bijay Jassal Steve Jupe NYU Peter D'Eustachio Lisa Matthews Veronica Shamovsky EU 6th Framework Programme grant LSHG-CT-2005-518254 "ENFIN" NHGRI Grant # U41 HG003751

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