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BIPN148 Lecture 11

BIPN148 Lecture 11. Regulation of AMPA receptors by phosphorylation. LTP-induced changes in AMPA currents. Effect of CaMKII on AMPA conductance. Glycine induces potentiation. Glycine increases surface GluR1. Trafficking of GluR1/2/3. Evidence for GluR1 insertion at synapses.

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BIPN148 Lecture 11

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  1. BIPN148 Lecture 11

  2. Regulation of AMPA receptors by phosphorylation

  3. LTP-induced changes in AMPA currents

  4. Effect of CaMKII on AMPA conductance

  5. Glycine induces potentiation

  6. Glycine increases surface GluR1

  7. Trafficking of GluR1/2/3

  8. Evidence for GluR1 insertion at synapses

  9. CaMKII effect of synaptic responses

  10. CaMKII delivers GluR1 to silent synapses

  11. Comparison of S831 (CKII), S845 (PKA)phosphorylations

  12. Generation of S831/845- mice

  13. Plasticity in S831/845- mice

  14. Comparison of S831A, T887A (C-tail) mutations on synaptic responses

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