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Health Care Disparities: A Focus on Hypertension. Brian K. Irons, PharmD, BCPS, BC-ADM Division Head – Primary Care Associate Professor School of Pharmacy. Objectives. Review Types and Causes of Healthcare Disparities Assess Disparities in HTN Awareness / Control / Treatment
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Health Care Disparities: A Focus on Hypertension Brian K. Irons, PharmD, BCPS, BC-ADM Division Head – Primary Care Associate Professor School of Pharmacy
Objectives • Review Types and Causes of Healthcare Disparities • Assess Disparities in HTN Awareness / Control / Treatment • Examine Ways to Minimize Disparities • General Measures • Role of Academia • Focus on HTN
Health Disparities / Inequities Race / Ethnicity
Health Disparities / Inequities Gender Race / Ethnicity
Health Disparities / Inequities Gender Race / Ethnicity Sexual Orientation
Health Disparities / Inequities Gender Race / Ethnicity Sexual Orientation Socioeconomic Group
Health Disparities / Inequities Gender Race / Ethnicity Sexual Orientation Socioeconomic Group Age
Health Disparities / Inequities Gender Race / Ethnicity Sexual Orientation Rural vs Urban Socioeconomic Group Age
Major Types of Disparities • Access to Care (Disparities in Health Care) • Quality of Care (Disparities in Health)
Causes of Disparities in Access to Care • Insurance coverage • Regular source of care • Delay in seeking care • Decrease in needed care • Financial resources • Legal barriers • Structural barriers
Quality /Access to Care: Insured vs Uninsured • Reduced Access to care • Poorer medical outcomes • Increased morbidities • Earlier mortality • Biggest impact on timeliness and quality of health care American College of Physicians 2004 Institute of Medicine 2001 2002
Population Base and Uninsured Annals Intern Med 2004;141:226
Causes of Disparities in Access to Care • Insurance coverage • Financial resources • Legal barriers • Structural barriers • Transportation • Scheduling • Employment issues
Causes of Disparities in Access to Care • Fragmentation of health care “system” • Provider scarcity • Language barriers • Health literacy • Healthcare beliefs • Age
Social Determinants in Disparities based on Race/Ethnicity Socioeconomic Status
Social Determinants in Disparities based on Race/Ethnicity Socioeconomic Status Inadequate Housing
Social Determinants in Disparities based on Race/Ethnicity Socioeconomic Status Inadequate Housing Proximity to Environmental Hazards
Social Determinants in Disparities based on Race/Ethnicity Socioeconomic Status Education Level Inadequate Housing Proximity to Environmental Hazards
Causes of Disparities in Quality of Care • Provider – Patient Communication • Provider Discrimination / Biases • Poor Preventative Care • Decreased patient satisfaction • Decreased adherence • Worse outcomes
Awareness / Treatment / Control of HypertensionDifferences between Races/Ethnicities and Age
Risks of Uncontrolled HTN Stroke Arrhythmias Myocardial Infarction Increased BP Cognition Retinopathy Nephropathy Heart Failure
Trends in HTN- Gender DHHS – CDC – NCHS 2009 Elevated BP or Taking BP Med
Trends in HTNRace/Ethnicity - Men DHHS – CDC – NCHS 2009 Elevated BP or Taking BP Med
Trends in HTNRace/Ethnicity - Women DHHS – CDC – NCHS 2009 Elevated BP or Taking BP Med
Trends in HTNIncome Poverty Level DHHS – CDC – NCHS 2009 Elevated BP or Taking BP Med
BP Differences: Medicare Eligibility Annals of Intern Med 2009;150:505
Prevalence of HTN – Dyslipidemia – DM2005-2006 NHANES CDC NHCS Data Brief #36 April 2010
HTN and Age Lloyd-Jones D, et al. Circulation. 2009.119; e21-e181.
Changes in SBP/DBP with Age NEJM 2007;357:789
BP-Age and Mortality from Heart Disease 80-89 yrs70-79 yrs 60-69 yrs 50-59 yrs 40-49 yrs Chobanian AV, et al. JNC 7. Hypertension. 2003; 42:1206 1252.
Fatal CAD Risk and Age • For the same Systolic BP • Patient 80-89 years of age versus 40-49 years • 16x risk for fatal CAD Circulation 2007;115
Minimize Disparities: Race/Ethnicity • Increase government offices of minority health • Expanded access • Raise awareness (Providers and Patients) • Health Disparities Roundtable • Federal Collaboration on Health Disparities Research • Disparity Reducing Advances Project • CMS’s Health Disparities Program • Healthy People 2010 and 2020
Minimizing Disparities in HTN Management : Age • Don’t assume benefits will be limited just because a patient is older • Don’t treat all older patients the same • Functional / Cognitive Status • Living Arrangements • Co-morbidities
Patient 1 81 yo WM No chronic medications No diagnosed chronic conditions Patient 2 66 yo HF Diagnosed with DM 12 years ago h/o CAD / CHF / CVA / HTN / Lipids / COPD On 17 meds Cognitively impaired Who is ‘Older’?
Benefits to Treating Isolated Systolic HTN 15,693 patients, mean age 70, initial BP 174/83, 3.8 yr follow-up Lancet 2000;355:865
Recommended HTN Treatments for Isolated Systolic HTN • SHEP / Syst-Eur Trials • Thiazide Diuretic • Dihydropyridine CCB • Approach and Goals similar to Essential HTN • < 140/90 mm Hg
Treating HTN in the Very Old Most trials excluded or simply didn’t recruit many very elderly patients (> 80) Meta-analysis in 1999 for those >80 Lancet 1999;353:793
Treating HTN in the Very Old • Retrospective Study in VA Patients > 80 years old • 85% taking antihypertensives • Shorter duration survival for those with SBP <140 mm Hg • “Clinicians should use caution in their approach to BP lowering in this age group” JAGS 2007;55:383
Hypertension in the Very Elderly Trial (HYVET) • 3845 patients 80+ years of age (mean 83.6 years) • Baseline BP: 173/91 • Indapamide vs placebo (perindopril added prn) • Target BP: < 150/80 • 1.8 years of follow-up • Primary outcome: Stroke (fatal and non) • Secondary outcomes: all cause mortality / CV mortality / CAD mortality / stroke mortality NEJM 2008;358:1887
Hypertension in the Very Elderly Trial (HYVET) NS Exp 143/78 vs placebo 158/84 NEJM 2008;358:1887
What is BP Goal in the Very Elderly? • No specific guideline… yet • < 150/80 ? • Reduces mortality, fatal stroke, HF • Does it cause cognitive problems, increase fall risk? • What about very elderly patients with existing CAD • Can we risk < 130/80?
Risks of BP Meds in the Elderly • Prone to ADRs • Lots of comorbidities / contraindications to look out for • Cognitive impairment • Compliance • Costs
Risks of BP Meds in the Elderly • Orthostatic hypotension • Sensitive to volume depletion / sympathetic inhibition • Increased risk for falls • Definition: • Sitting to standing drop in BP (usually increase in heart rate) • >20 mm difference in SBP / >10 mm dif in DBP
Strategies for HTN Medication use in Elderly • Start low and go slow • COMMUNICATE • Once daily regimens if compliance issues • Avoid central acting agonists and alpha-blockers • Caution with beta-blockers without a compelling co-morbidity