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Cost-Effectiveness of Screening in the National Lung Screening Trial. William C. Black, MD Dartmouth-Hitchcock Medical Center. Working Group. NLST CEA. Comparison: LDCT vs CXR vs None Effectiveness: LYs and QALYs Costs: $ US (reference 2009) Perspective: Societal
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Cost-Effectiveness of Screening in the National Lung Screening Trial William C. Black, MD Dartmouth-Hitchcock Medical Center
NLST CEA • Comparison: LDCT vs CXR vs None • Effectiveness: LYs and QALYs • Costs: $US (reference 2009) • Perspective: Societal • Time horizon: Within-trial and lifetime • Discount rate: 3% .
Effectiveness • Aggregate LYs from entry to death • Observed survival before 2009 • Projected survival after 2009 • age, sex, lung ca stage, smoking
Effectiveness (cont) • Adjust LYs for QOL (0-1.0) • SF-6D utility scoring • Estimate missing scores • age, sex, scr, lung ca Brazier et al. JHE 2002; 21:271-92
Costs • Direct medical (screening, dx, rx) • Non-medical (travel, lodging) • Opportunity (lost wages) • Projected beyond 2009 - age, sex, and lung ca stage
Direct Medical Costs • Utilization based on med abstraction • Estimate/ impute missing utilization • Multiply by Medicare prices
ICER = ∆COSTS ∆QALYS
Baseline Results • LYs, QALYs & Costs • ICERs • Subset analyses • age, sex, smokhx, co-morbidity
Uncertainty • Sensitivity analysis • Scatter plot of ICE • CE Acceptability curves
Incremental Cost K II IB IA Incremental Effect IIIA IIIB IV Black WC. Med Decis Making 1990;10:212-4
Developed analytic approach using R Completed analysis of “enriched” DHMC subset Developed plan for managing missing data Obtained approval to reuse Medicare data Developed algorithms for projecting survival Selected relevant CPT and DRG codes Accomplishments .
Next Steps • Estimate Medicare payments for DRGs • Extract utilization and QOL from ACRIN dataset • Analyze Medicare data & adjust cost estimates • Impute and/or estimate missing data elements • Analyze completed NLST CEA dataset in R • Write up results and submit .
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