Alex

1. Alex Koopman WJ, Distelmaier F, Hink M, Verkaart S, Wijers M, Fransen J, Smeitink J, Willems P Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria.Am J Physiol Cell Physiol. 2008 Mar 19; Schneider D, Pohl T, Walter J, Dorner K, Kohlstadt M, Berger A, Spehr V, Friedrich T Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).Biochim Biophys Acta. 2008 Mar 15;. The Small-Molecule Iron Transport Inhibitor Ferristatin/NSC306711 Promotes Degradation of the Transferrin ReceptorL. Horonchik and M. Wessling-Resnick Whitnall M, Rahmanto YS, Sutak R, Xu X, Becker EM, Mikhael MR, Ponka P, Richardson DR. The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9757-62. Garmier M, Carroll AJ, Delannoy E, Vallet C, Day DA, Small ID, Millar AH. Complex I dysfunction redirects cellular and mitochondrial metabolism in Arabidopsis. Plant Physiol. 2008 Sep 10;. Hirst J, King MS, Pryde KR. The production of reactive oxygen species by complex I. Biochem Soc Trans. 2008 Oct;36(Pt 5):976-80. Dieteren CE, Willems PH, Vogel RO, Swarts HG, Fransen J, Roepman R, Crienen G, Smeitink JA, Nijtmans LG, Koopman WJ. Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells. J Biol Chem. 2008 Sep 30;.

2. Antonio Pugh RA, Honda M, Leesley H, Thomas A, Lin Y, Nilges MJ, Cann IK, Spies M. The iron-containing domain is essential in RAD3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the ssDNA-dsDNA junction. J Biol Chem. 2007 Nov 20; Kulkarni A, Wilson DM 3rd. The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction. Am J Hum Genet. 2008 Mar;82(3):539-66. Huang Q, Hong X, Hao QRelatedArticlesSNAP-25 is also an iron-sulfur protein.FEBS Lett. 2008 Mar 28;. XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD MutationsL. Fan, J.O. Fuss, Q.J. Cheng, A.S. Arvai, M. Hammel, V.A. Roberts, P.K. Cooper, and J.A. TainerStructure of the DNA Repair Helicase XPDH. Liu, J. Rudolf, K.A. Johnson, S.A. McMahon, M. Oke, L. Carter, A.-M. McRobbie, S.E. Brown, J.H. Naismith, and M.F. White Wolski SC, Kuper J, Hänzelmann P, Truglio JJ, Croteau DL, Van Houten B, Kisker C. Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol. 2008 Jun 24;6(6):e149. Münck E, Bominaar EL. CHEMISTRY: Bringing Stability to Highly Reduced Iron-Sulfur Clusters. Science. 2008 Sep 12;321(5895):1452-1453. Ingavale SS, Chang YC, Lee H, McClelland CM, Leong ML, Kwon-Chung KJ. Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride. PLoS Pathog. 2008 Sep 19;4(9):e1000155.

3. Daili Lu J, Yang J, Tan G, Ding HRelatedArticles Complementary roles of SufA and IscA in the biogenesis of iron-sulfur clusters in Escherichia coli.Biochem J. 2007 Oct 17;. Muller JM, Milenkovic D, Guiard B, Pfanner N, Chacinska A Precursor Oxidation by Mia40 and Erv1 Promotes Vectorial Transport of Proteins into the Mitochondrial Intermembrane Space.Mol Biol Cell. 2007 Oct 31;. Todorovic S, Justino MC, Wellenreuther G, Hildebrandt P, Murgida DH, Meyer-Klaucke W, Saraiva LM Iron-sulfur repair YtfE protein from Escherichia coli: structural characterization of the di-iron center.J Biol Inorg Chem. 2008 Mar 21;. Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, McBride HM Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol. 2008 Jan 22;18(2):102-8. Jin Z, Heinnickel M, Krebs C, Shen G, Golbeck JH, Bryant DA. Biogenesis of iron-sulfur clusters in photosystem I: Holo-NfuA from the cyanobacterium Synechococcus sp. PCC 7002 rapidly and efficiently transfers [4Fe-4S] clusters to apo-PsaC in vitro. J Biol Chem. 2008 Aug 11;.

4. Holger Angelini S, Gerez C, Ollagnier-de Choudens S, Sanakis Y, Fontecave M, Barras F, Py B NfuA, a new factor required for maturing Fe/S proteins in Escherichia coli under oxidative stress and iron starvation conditions.J Biol Chem. 2008 Mar 13;. Bandyopadhyay S, Naik SG, O'Carroll IP, Huynh BH, Dean DR, Johnson MK, Dos Santos PC A proposed role for the Azotobacter vinelandii NfuA protein as an intermediate iron-sulfur cluster carrier.J Biol Chem. 2008 Mar 13; Yabe T, Yamashita E, Kikuchi A, Morimoto K, Nakagawa A, Tsukihara T, Nakai M. Structural analysis of Arabidopsis CnfU protein: an iron-sulfur cluster biosynthetic scaffold in chloroplasts. J Mol Biol. 2008 Aug 1;381(1):160-73. Füzéry AK, Tonelli M, Ta DT, Cornilescu G, Vickery LE, Markley JL. Solution Structure of the Iron-Sulfur Cluster Cochaperone HscB and Its Binding Surface for the Iron-Sulfur Assembly Scaffold Protein IscU. Biochemistry. 2008 Aug 15;. The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane HemojuvelinL. Silvestri, A. Pagani, A. Nai, I. De Domenico, J. Kaplan, and C. Camaschella

5. Judita The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast      Erin Easlon, Felicia Tsang, Craig Skinner, Chen Wang, and Su-Ju Lin      Genes Dev. 2008;22 931-944 Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape      Lilli Winter, Christina Abrahamsberg, and Gerhard Wiche      J. Cell Biol. 2008;181 903-911,      http://www.jcb.org/cgi/content/abstract/181/6/903?etoc Cooperation of Two mRNA-Binding Proteins Drives Metabolic Adaptation to Iron DeficiencyS. Puig, S.V. Vergara, and D.J. Thiele, Cell Metabolism

6. Oliver Sutak R, Xu X, Whitnall M, Kashem MA, Vyoral D, Richardson DR Proteomic analysis of hearts from frataxin knockout mice: Marked rearrangement of energy metabolism, a response to cellular stress and altered expression of proteins involved in cell structure, motility and metabolism.Proteomics. 2008 Mar 13;. Schagerlof U, Elmlund H, Gakh O, Nordlund G, Hebert H, Lindahl M, Isaya G, Al-Karadaghi S Structural Basis of the Iron Storage Function of Frataxin from Single-Particle Reconstruction of the Iron-Loaded Oligomer. Biochemistry. 2008 Apr 5; Review: Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway W.G. Kaelin, Jr. and P.J. Ratcliffe Li K, Besse EK, Ha D, Kovtunovych G, Rouault TA. Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. Hum Mol Genet. 2008 Apr 17. [Epub ahead of print] Whitnall M, Rahmanto YS, Sutak R, Xu X, Becker EM, Mikhael MR, Ponka P, Richardson DR. The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9757-62. Schmucker S, Argentini M, Carelle-Calmels N, Martelli A, Puccio H. The in vivo mitochondrial two-step maturation of human frataxin. Hum Mol Genet. 2008 Aug 25;. Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell DeathA. Seiler, M. Schneider, H. Förster, S. Roth, E.K. Wirth, C. Culmsee, N. Plesnila, E. Kremmer, O. Rådmark, W. Wurst, G.W. Bornkamm, U. Schweizer, and M. Conrad Cell Metab. Long S, Jirku M, Ayala FJ, Lukes J. Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei. Proc Natl Acad Sci U S A. 2008 Sep 3;. Kakhlon O, Manning H, Breuer W, Melamed-Book N, Lu C, Cortopassi G, Munnich A, Cabantchik ZI. Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation. Blood. 2008 Sep 16;.

7. Roland Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL A heme export protein is required for red blood cell differentiation and iron homeostasis.Science. 2008 Feb 8;319(5864):825-8. Ross DSA Quantitative Evaluation of the Iron-Sulfur World and Its Relevance to Life's Origins.Astrobiology. 2008 Apr;8(2):267-72. A Novel Heme-Regulatory Motif Mediates Heme-Dependent Degradation of the Circadian Factor Period 2 Jianhua Yang, Kevin D. Kim, Andrew Lucas, Karen E. Drahos, Carlo S. Santos, Sean P. Mury, Daniel G. S. Capelluto, and Carla V. Finkielstein Mol. Cell. Biol. 2008;28 4697-4711 Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA. Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Proc Natl Acad Sci U S A. 2008 Aug 6;. [Epub ahead of print] Nakai Y, Nakai M, Hayashi H. Thio modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems. J Biol Chem. 2008 Jul 29;. Xu XM, Møller SG. Iron-Sulfur Cluster Biogenesis Systems and their Crosstalk. Chembiochem. 2008 Sep 16;.

8. Sabine Williams BA, Cali A, Takvorian PM, Keeling PJDistinct Localization Patterns of Two Putative Mitochondrial Proteins in the Microsporidian Encephalitozoon cuniculi.J Eukaryot Microbiol. 2008 Mar-Apr;55(2):131-3. Stechmann A, Hamblin K, Pérez-Brocal V, Gaston D, Richmond GS, van der Giezen M, Clark CG, Roger AJ. Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes. Curr Biol. 2008 Apr 22;18(8):580-5. Epub 2008 Apr 10. Superoxide Flashes in Single Mitochondria W. Wang, H. Fang, L. Groom, A. Cheng, W. Zhang, J. Liu, X. Wang, K. Li, P. Han, M. Zheng, J. Yin, W. Wang, M.P. Mattson, J.P.Y. Kao, E.G. Lakatta, S.-S. Sheu, K. Ouyang, J. Chen, R.T. Dirksen, and H. Cheng Aldridge C, Spence E, Kirkilionis MA, Frigerio L, Robinson C. Tat-dependent targeting of Rieske iron-sulfur proteins to both the plasma and thylakoid membrane in the cyanobacterium Synechocystis PCC6803. Mol Microbiol. 2008 Aug 11;. [Epub ahead of print] Gakh O, Smith Iv DY, Isaya G. Assembly of the iron-binding protein frataxin in S. cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level. J Biol Chem. 2008 Sep 9;.

9. Torsten Moosmann B, Behl C Mitochondrially encoded cysteine predicts animal lifespan.Aging Cell. 2007 Nov 19;. Rothery RA, Workun GJ, Weiner JH The prokaryotic complex iron-sulfur molybdoenzyme family.Biochim Biophys Acta. 2007 Sep 18;. The Hepcidin-Binding Site on Ferroportin Is Evolutionarily ConservedI. De Domenico, E. Nemeth, J.M. Nelson, J.D. Phillips, R.S. Ajioka, M.S. Kay, J.P. Kushner, T. Ganz, D.M. Ward, and J. Kaplan Hu J, Dong L, Outten CE. The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J Biol Chem. 2008 Aug 15;.

10. Uli Abdel-Hamid AM, Cronan JE. In vivo resolution of conflicting in vitro results: synthesis of biotin from dethiobiotin does not require pyridoxal phosphate. Chem Biol. 2007 Nov;14(11):1215-20. • The N-end rule pathway is a sensor of heme • Rong-Gui Hu, Haiqing Wang, Zanxian Xia, and Alexander Varshavsky • PNAS Jan. 08 Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast      Liangtao Li, Dustin Bagley, Diane M. Ward, and Jerry Kaplan      Mol. Cell. Biol. 2008;28 1326-1337 Jiang H, Zhang X, Ai C, Liu Y, Liu J, Qiu G, Zeng J. Asp97 is a Crucial Residue Involved in the Ligation of the [Fe4S4] Cluster of IscA from Acidithiobacillus ferrooxidans. J Microbiol Biotechnol. 2008 Jun;18(6):1070-1075. Comini MA, Rettig J, Dirdjaja N, Hanschmann EM, Berndt C, Krauth-Siegel RL. Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes. J Biol Chem. 2008 Jul 31;. Taylor AM, Farrar CE, Jarrett JT. 9-Mercaptodethiobiotin Is Formed as a Competent Catalytic Intermediate by Escherichia coli Biotin Synthase. Biochemistry. 2008 Aug 9;. Gibson LM, Dingra NN, Outten CE, Lebioda L. Structure of the thioredoxin-like domain of yeast glutaredoxin 3. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):927-32.