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The Ocean Genome Legacy

The Ocean Genome Legacy. Daniel L. Distel, Ph.D., Executive Director, Ocean Genome Legacy Foundation. Goals for this presentation. Recruit collaborators among CoML participants Propose a meeting to facilitate CoML collaborations. OGL.

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The Ocean Genome Legacy

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  1. The Ocean Genome Legacy Daniel L. Distel, Ph.D., Executive Director, Ocean Genome Legacy Foundation

  2. Goals for this presentation • Recruit collaborators among CoML participants • Propose a meeting to facilitate CoML collaborations

  3. OGL • OGL is a publicly supported non-profit, non-governmental organization: • US public agencies • Private agencies • Corporate sponsors • Individual donors Richard Lounsbery Foundation Francis Goelet Charitable Lead Trust

  4. Ocean Genome Legacy • Mission: • to explore, preserve and protect the genetic biodiversity of the oceans • by creating a network of marine-dedicated public DNA banks

  5. Center for Marine Genomic Research Cryogenic storage facility OGL Headquarters DNA laboratory Laboratories Sample processing Cryogenic storage Data management

  6. Biobanking: not such a new idea

  7. Biobanks • Blood • Tissue • Reproductive products • Embryos • Tumors • Genetic materials

  8. Biobank’s purpose • Preserve biomaterials for future use and retrospective studies • To bring together biomaterials, data and researchers • Promote research, stimulate new ideas, and make better use of available resources. • Proven value for medical research but few repositories dedicated to natural biodiversity

  9. Ocean Genome Resource • First public biological repository dedicated to preserving genomic materials from marine organisms • Directly serving the scientific community • Independent of government agencies and other private and public institutions.

  10. Value of archived genomes • Species identification • Evolutionary history • Ecological functions • Physiological capabilities • Population biology • Forensic information • Valuable Genes

  11. How OGL works Collection & Identification Preservation & Storage DNA extraction Distribution

  12. Sample Submission Kit • Barcoded tubes • Sample spreadsheet • Fixative • Instructions • Shipping materials • Prepaid shipping labels

  13. Ocean Genome Resource Summary of Collection Holdings Total accessioned samples (as of 8/15/08) All types............................................ > 1300 Number of species............................ > 200 Number of phyla................................ 13 Number of contributors...................... 36

  14. OGL Partners • New England Aquarium • Bermuda Museum of Natural History • Philippine Marine Mollusk International Cooperative Biodiversity Group (ICBG)

  15. Philippine Marine Mollusk ICBG • 5-year, $4 million project that combines • a large scale biodiversity survey • biodiversity-based drug discovery efforts • Funded by US NIH, NSF, DOE • $250K for DNA archiving • 5 institutions: • Oregon Health Sciences University • University of Utah • University of the Philippines • Academy of Natural Sciences, Philadelphia • Ocean Genome Legacy • Partnership with Philippine Govt. and Institutions

  16. Summary • OGL has developed basic methods, capabilities and policies for DNA archiving • Seeking collaborators • specimens and taxonomic expertise • partners in efforts to gain grant support to integrate research and archival activities • DNA archiving workshop

  17. Finis

  18. The ICBG Model • Biodiversity as a source potential therapeutic compounds • supports new drug discovery • enhancing biodiversity conservation • Incentives for host nations • Economic development and building of research capacity • Formalized access and benefit sharing agreements • Intellectual property agreements prior to start of research

  19. Workshop goals • Focus of practical considerations • Priorities for archiving • Methods development • Strategies for coordination of activities • Development of resources

  20. OGR database

  21. Taxonomically Intelligent Search Box (also can search any other database field) Social Bookmarking Database filters Advanced Search External Links Last Ten… Serendipity Browsing e.g., “last ten samples”, “most popular specimens” Samples Specimen Voucher Participant … Location Tabbed database results Results Zone Results Zone

  22. ICBG • Project title: • Drug and energy lead compounds from Philippine mollusks • Project description: • Biodiversity survey and conservation management plan • Search for new drug and bioenergy compounds derived from marine mollusks and their bacterial symbionts

  23. OGL Progress NEAq Bermuda ICBG

  24. What is a Genome? • Genome = sum of all the genetic material (DNA) in an individual cell • Contains all of the information needed to build and operate a complete living organism

  25. Population History Roman & Palumbi, Science. 2003 Jul 25;301(5632):451 Photo: Brandon Cole/Nature 424:479 (2003)

  26. OGR goals • Archive: to preserve and make available at cost genomic materials for future use and retrospective studies • Forum: for sharing biomaterials, data, information, and ideas, to simulate collaboration and to make better use of available resources. • Catalyst and Community Resource: to promote research that can protect species and environments • For more information www.oglf.org

  27. Who benefits?

  28. ICBG • Margo Haygood (Lead PI): Oregon Health Sciences • Toto Olivera & Eric Schmidt: University of Utah • Gisselle Concepcion: University of the Philippines • Gary Rosenburg: Academy of Natural Sciences • Dan Distel: Ocean Genome Legacy

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