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Understanding Propofol: Uses, Side Effects, and Restrictions

Learn about propofol, an anesthetic used for surgery, its development, molecular modifications, side effects, and restrictions. Discover the benefits and risks associated with this popular intravenous general anesthetic agent.

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Understanding Propofol: Uses, Side Effects, and Restrictions

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  1. MJ died on 25thJune, 09

  2. Conrad Murray Propofol

  3. What is Propofol ?

  4. Propofol is • An anesthetic. • Used to produce relaxation and sleep before or during surgery. • An extremely popular intravenous general anesthetic agent due to several favorable characteristics. Anti-emetic effect A general state of euphoria Rapid emergence from unconsciousness with minimal residual drowsiness

  5. Propofol appears as a highly opaque-white fluid

  6. Development of propofol • Initial clinical trials in 1977 in a form solubilised in Cremophor EL(a kind of drug additive acts as surfactant). • However there are severe allergic reaction, and it was reformulated as an emulsion of propofol with soya oil in water. • Newer generic formulation contain metabisulphite.(a carrier of the active ingredients [propofol])

  7. Alkaline phosphatase Molecular modification Recently, a water soluble form – fospropofol (2,6-diisopropopylphenoxymethyl phosphate disodium) is developed. The fospropofol is found to break down to propofol in the body by the enzyme alkaline phosphatase in vivo.

  8. As fospofol is water soluble, it is more readily to inject and minimize the pain at the injection site. • The fospropofol was approved by USFDA in 2008.

  9. Side effects • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue • breathing problems, stomach pain • changes in vision • dark urine • fast, irregular heartbeat • low blood pressure • pain at site where injected • addicted

  10. Restriction • heart disease • high cholesterol • an unusual or allergic reaction to propofol, anesthetics, eggs, soy, benzyl alcohol, sulfites, other medicines, foods, dyes, or preservatives • pregnant or trying to get pregnant • breast-feeding • infant

  11. Thank you! Group members: Chow Chi Wai (4) Wan Kin (24)

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