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R egulasi sistem reproduksi jantan

R egulasi sistem reproduksi jantan. 1. Regulasi organ reproduksi jantan : testis, skrotum, epididimis, vas deferent, uretra, dan kelenjar asesoris 2. Struktur pendukung: jaringan saraf dan peredaran darah. Pengaturan di TESTIS. Spermatogenesis Hormonal control.

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R egulasi sistem reproduksi jantan

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  1. Regulasi sistem reproduksi jantan

  2. 1. Regulasi organ reproduksi jantan: • testis, • skrotum, • epididimis, • vas deferent, • uretra, dan • kelenjar asesoris • 2. Struktur pendukung: • jaringan saraf dan • peredaran darah

  3. Pengaturandi TESTIS • Spermatogenesis • Hormonal control

  4. Produksi Spermatozoa • Seminiferous tubules • Spermatids • Spermatocytes • Spermatozoa • Sertoli cells • Interstitial tissue • Leydig cells • Capillaries

  5. Spermatozoa Structure and Functions • Head • Acrosome • Nucleus • Midpiece • Centrioles • Mitochondria • Tail: flagellum • Microtubules Figure 26-10: Sperm structure

  6. Testicular Compartmentalization

  7. SelSertoli

  8. FungsiselSertoli • Nourish healthy cells & phagocytize damaged germ cells • Synthesize luminal proteins • Maintain tubular fluid • Convert androgens to estrogens

  9. The blood-testis barrier (BTB) • BTB (in rats)  composed: • tight junction • basal ectoplasmic specialization • basal tubulobulbar complex • desmosome-like junction, at side-by-side in the seminiferous epithelium

  10. Tight junctions sebagai tempat komunikasi antar sel TIGHTJUNCTION ANCHORING JUNCTION COMMUNICATING JUNCTION Plasma membranes ofadjacent cells Extracellularmatrix

  11. The BTB physically  divides the seminiferous epithelium into basal and apical compartments  spermatogenesis • The function: • Immunological barrier -cell antigens from the systemic circulation, • Creates a microenvironment for germ-cell development

  12. Spermatogenesis  the BTB to permit the preleptotene & leptotene spermatocytes (Late stage VII - VIII of the epithelial cycle) • BTB to facilitate germ-cell migration is regulated two cytokines to activated protein kinases: • 1. Transforming Growth Factor-beta3 (TGF-beta3) • 2. tumor necrosis factor-alpha (TNFalpha)

  13. SelIntersisial • Terletak di antara seminiferous tubules • Di jumpai banyak kapiler darah dan populasi sel somatik lainnya • Menghasilkan hormone testosteron (Franz von Leydig, 1821-1908, German) • Bentuk: cuboidal & in groups of 2-20 cells • Testosteron menstimuli perkembangan sek sekunder jantan (rambut & bentuk tubuh) • The pituitary hormone ICSH (Interstitial Cell Stimulating Hormone) menstimuli produksi testosteron saat puber

  14. Leydig cells

  15. SaluranReproduksi: • Rete Testis • channels lined with a low cuboidal epithelium, like channels in a river delta • Efferent ducts • The efferent ducts (7-15 seminiferous tubules ) • Epididymis • Long & extremely coiled single duct • Extra testicular organ • Ductus Deferens • relatively short & highly coiled ducts • pseudostratified columnar epithelium

  16. Rete Testis

  17. Efferent ducts

  18. Epididymis

  19. KelenjarAsesoris • Prostate gland • radially around the urethra (upper right) • 20% total volume semen • Seminal Vesicle • 60 % total volume semen • Bulbourethral gland (Cowper gland) • Ejaculat • pH 7,2-8,2

  20. Penis • Tersusunatas: • Korpusspongiosum: terletakdisekitaruretra, penuhkapilerdarah • Korpuscavernosum: terletakdibagian dorsal, terdapatpembuluhdarahbesar

  21. Pengaturanseresi protein epididymis Sintesis protein di epididymis: tergantung konsentrasi androgen dan kepekatan cairan Sintesis hormon steroid: 5-alpha dihydroxytestosterone (DHT), disekresikan di sitoplasma bagian caput, corpus, & cauda Secretion of epididymal segments → epithelium epididymal In rats, the proximal & in the distal epididymis → * the proximal epididymis → 27 & 29-kD * the distal epididymis → 32-40 kD

  22. TERIMA KASIH ATAS PERHATIANNYA

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