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. Disclosures . J. Aoki, J. Moses, H. Parise, M.B. Leon NoneG.W. Stone, E. Ohman Consultant and advisory board from the Medicines CompanyR. MehranResearch grant and speakers bureau from the Medicines CompanyH.D. WhiteResearch grant and honoraria from the Medicines CompanyA. Lincoff, A. Lansk
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1. Jiro Aoki, MD, Gregg W. Stone, MD, Roxana Mehran, MD, Jeffery Moses, MD, Michel E. Bertrand, MD, A. Michael Lincoff, MD, E. Magnus Ohman, MD, Harvey D. White, DSc, Helen Parise ScD, Martin B. Leon, MD, Alexandra J. Lansky, MD Subacute Stent Thrombosis in Patients with Acute Coronary Syndromes Treated with Bare Metal and Drug-Eluting Stents: The ACUITY Trial
3. DES use in patients with ACS
5. ACUITY - Study Design
6. Patient Population – This Study
7. Definite stent thrombosis
Angiographic confirmation of stent thrombosis
The presence of a thrombus that originates in the stent or in the segment 5 mm proximal or distal to the stent and presence of at least 1 of the following criteria within a 48-hour time window:
• Acute onset of ischemic symptoms at rest
• New ischemic ECG changes that suggest acute ischemia
• Typical rise and fall in cardiac biomarkers (refer to definition of spontaneous MI)
Pathological confirmation of stent thrombosis
Probable stent thrombosis
Clinical definition of probable stent thrombosis is considered to have occurred after intracoronary stenting in the following cases:
• Any unexplained death within the first 30 days
• Irrespective of the time after the index procedure, any MI that is related to
documented acute ischemia in the territory of the implanted stent without
angiographic confirmation of stent thrombosis and in the absence of any other
obvious cause Stent Thrombosis Definition
8. Incidence of Subacute Stent Thrombosis
9. Incidence of Subacute Stent Thrombosis
10. Occurrence and Frequency of Stent Thrombosis From Day 0 To 30