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Prevention of Diabetes

Prevention of Diabetes. Key Messages As safe and effective preventive therapies for type 1 diabetes have not yet been identified, any attempts to prevent type 1 diabetes should be undertaken only within the confines of formal research protocols.

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Prevention of Diabetes

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  1. Prevention of Diabetes Key Messages • As safe and effective preventive therapies for type 1 diabetes have not yet been identified, any attempts to prevent type 1 diabetes should be undertaken only within the confines of formal research protocols. • Intensive and structured lifestyle modification that results in loss of approximately 5% of initial body weight can reduce the risk of progression from impaired glucose tolerance to type 2 diabetes by almost 60%.

  2. Prevention of Diabetes Key Messages • Progression from prediabetes to type 2 diabetes can also be reduced by pharmacologic therapy with metformin (~30% reduction), acarbose (~30% reduction) and thiazolidinedione (~60% reduction).

  3. Prevention of Diabetes 2008 CPG Recommendations • A structured program of lifestyle modification that includes moderate weight loss and regular physical activity should be implemented to reduce the risk of type 2 diabetes in individuals with IGT [Grade A, Level 1A (12,13)] and IFG [Grade D, Consensus].

  4. Prevention of Diabetes 2008 CPG Recommendations • In individuals with IGT, pharmacologic therapy with a biguanide (metformin) [Grade A, Level 1A (13)] or an alpha-glucosidase inhibitor [Grade A, Level 1A (19)] should be considered to reduce the risk of type 2 diabetes. In individuals with IGT and/or IFG and no known cardiovascular disease, treatment with a thiazolidinedione could be considered to reduce the risk of type 2 diabetes [Grade A, Level 1A (23)].

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