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fMRI Setup

fMRI Setup. slice orientations. sagittal. coronal. axial. SPGR Anatomics (1). resolution in-plane 0.9375 mm 2 through-plane 1.5 mm. SPGR Anatomics (2). SPGR Anatomics (3). Diffusion-Weighted Imaging (1). Diffusion-Weighted Imaging (2). Diffusion-Weighted Imaging (3). Slice Locations.

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fMRI Setup

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  1. fMRI Setup

  2. slice orientations sagittal coronal axial

  3. SPGR Anatomics (1) resolution in-plane 0.9375 mm2 through-plane 1.5 mm

  4. SPGR Anatomics (2)

  5. SPGR Anatomics (3)

  6. Diffusion-Weighted Imaging (1)

  7. Diffusion-Weighted Imaging (2)

  8. Diffusion-Weighted Imaging (3)

  9. Slice Locations

  10. Auditory versus Visual Sentence Task common print(red) speech(blue) R - L Constable, Pugh et al., (NeuroImage 2004)

  11. An Initial Neurobiological Reading Model (Pugh et al. 2000) • TEMPOROPARIETAL • (DORSAL) • Areas: • supramarginal, angular, superior temporal (Wernicke’s) gyri • Hypothesized Function: • Mapping of orthographic to phonological and semantic representations • ANTERIOR • Areas: • inferior frontal gyrus (including Broca’s area) • One Hypothesized Function: • Articulatory recoding OCCIPITOTEMPORAL (VENTRAL) Areas: occipitotemporal juncture, middle and inferior temporal gyri Hypothesized Function: Linguistically structured memory- based fast word identification system (posterior aspect = “word-form” area)

  12. Auditory versus Visual Sentence Task common print(red) speech(blue) temporoparietal anterior occipitotemporal R - L Constable, Pugh et al., (NeuroImage 2004)

  13. Vasculature Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

  14. Vasculature Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

  15. Simulated Hemodynamic Response (1) mean = 5000 sd = 100 effect size 0-1%, 0-50 points Gamma function tau=1.08; n=3; delay=3

  16. Variability of the HRF (1) Meizin et al., 2000

  17. Simulated Hemodynamic Response (2) Noise SD = 0 Noise SD = 10 Noise SD = 100

  18. Estimating the Response (3):Simple Subtraction with Overlap Dale & Buckner, 1997

  19. Linear Deconvolution Neuronal activity is modeled as a sequence of point events. slide courtesy of Matthew Brown, University of Western Ontario

  20. Functional Connectivity activations in Shaywitz et al. 2002 older good readers 74 good readers 7-18 yrs 70 dyslexic readers 7-18 yrs

  21. Functional Connectivity seed voxel correlations older good readers

  22. Functional Connectivity Younger Non-Impaired Older Non-Impaired univariate correlations Older Dyslexics Younger Dyslexics

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