1 / 3

Dose-Response and Critical Window Dioxins, Furans and PCBs - Hearing Loss

Dose-Response and Critical Window Dioxins, Furans and PCBs - Hearing Loss. Binding to PXR. Hepatic Parent or Metabolite. Exposure. Hepatic Phase II Enzymes. Binding to AhR. Alter TR Mediated Proteins. Loss of cochlear hair cells.  Serum T4 & T3.  Tissue T3. Hearing

minh
Download Presentation

Dose-Response and Critical Window Dioxins, Furans and PCBs - Hearing Loss

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Dose-Response and Critical WindowDioxins, Furans and PCBs - Hearing Loss Binding to PXR Hepatic Parent or Metabolite Exposure Hepatic Phase II Enzymes Binding to AhR Alter TR Mediated Proteins Loss of cochlear hair cells  Serum T4 & T3  Tissue T3 Hearing Loss

  2. Dose-Response Perchlorate, Propylthiouracil and Hippocampal Physiology Thyroid PTU Binding to TPO Exposure  Serum T4 & T3 Thyroid Perchlorate Inhibition Of TPO Alter TR Mediated Proteins  Hippocampal T3 Synaptic Malformation Altered Synaptic Function Learning Impariment

  3. Adverse Outcome Pathways for Thyroid Disruption Subcellular Target Cells Effected Adverse Outcome Chemical Tissue/Organ Thyroid Follicular Cells  T4 Synthesis  Serum T4 Methimazole TPO Enzyme Inhibition Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Thyroid Follicular Cells  T4 Synthesis  Serum T4 Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Perchlorate NIS Inhibition Toxicity Pathway Adverse Outcomes Pathway Amphibian Metamorphosis Assay

More Related