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Dose-Response and Critical Window Dioxins, Furans and PCBs - Hearing Loss. Binding to PXR. Hepatic Parent or Metabolite. Exposure. Hepatic Phase II Enzymes. Binding to AhR. Alter TR Mediated Proteins. Loss of cochlear hair cells. Serum T4 & T3. Tissue T3. Hearing
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Dose-Response and Critical WindowDioxins, Furans and PCBs - Hearing Loss Binding to PXR Hepatic Parent or Metabolite Exposure Hepatic Phase II Enzymes Binding to AhR Alter TR Mediated Proteins Loss of cochlear hair cells Serum T4 & T3 Tissue T3 Hearing Loss
Dose-Response Perchlorate, Propylthiouracil and Hippocampal Physiology Thyroid PTU Binding to TPO Exposure Serum T4 & T3 Thyroid Perchlorate Inhibition Of TPO Alter TR Mediated Proteins Hippocampal T3 Synaptic Malformation Altered Synaptic Function Learning Impariment
Adverse Outcome Pathways for Thyroid Disruption Subcellular Target Cells Effected Adverse Outcome Chemical Tissue/Organ Thyroid Follicular Cells T4 Synthesis Serum T4 Methimazole TPO Enzyme Inhibition Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Thyroid Follicular Cells T4 Synthesis Serum T4 Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Perchlorate NIS Inhibition Toxicity Pathway Adverse Outcomes Pathway Amphibian Metamorphosis Assay