Dose-Response and Critical Window Dioxins, Furans and PCBs - Hearing Loss

1. Dose-Response and Critical WindowDioxins, Furans and PCBs - Hearing Loss Binding to PXR Hepatic Parent or Metabolite Exposure Hepatic Phase II Enzymes Binding to AhR Alter TR Mediated Proteins Loss of cochlear hair cells  Serum T4 & T3  Tissue T3 Hearing Loss

2. Dose-Response Perchlorate, Propylthiouracil and Hippocampal Physiology Thyroid PTU Binding to TPO Exposure  Serum T4 & T3 Thyroid Perchlorate Inhibition Of TPO Alter TR Mediated Proteins  Hippocampal T3 Synaptic Malformation Altered Synaptic Function Learning Impariment

3. Adverse Outcome Pathways for Thyroid Disruption Subcellular Target Cells Effected Adverse Outcome Chemical Tissue/Organ Thyroid Follicular Cells  T4 Synthesis  Serum T4 Methimazole TPO Enzyme Inhibition Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Thyroid Follicular Cells  T4 Synthesis  Serum T4 Systemic T4 Insufficiency Arrested Amphibian Metamorphosis Perchlorate NIS Inhibition Toxicity Pathway Adverse Outcomes Pathway Amphibian Metamorphosis Assay