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QIBA DCE-MRI Technical Committee

QIBA DCE-MRI Technical Committee. Jeffrey L. Evelhoch, PhD Executive Director, Medical Sciences Head, Imaging Sciences. MEDICAL IMAGING CONTINUUM Path Forward for Advancing the Uses of Medical Imaging in the Development of New Biopharmaceutical Products 2-3 October 2008 Bethesda, MD.

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QIBA DCE-MRI Technical Committee

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  1. QIBA DCE-MRI Technical Committee Jeffrey L. Evelhoch, PhD Executive Director, Medical Sciences Head, Imaging Sciences MEDICAL IMAGING CONTINUUM Path Forward for Advancing the Uses of Medical Imaging in the Development of New Biopharmaceutical Products 2-3 October 2008 Bethesda, MD

  2. M. Buonocore (UC Davis) E. Jackson (MDACC) G. Karczmar (Chicago) D. Barboriak (Duke) M. Rosen (Penn) M. Schnall (Penn) M. Knopp (OSU) G. Zahlmann (Siemens) D. Purdy (Siemens) S. Gupta (GE) L. Hilaire (GE) G. Slavin (Philips) E. Ashton (VirtualScopics) A. Schmid (Perceptive) Members

  3. Motivation • Pre-treatment tumor vascularization and/or early changes in tumor vascularization in response to treatment could identify patients most likely to benefit from treatment, particularly vascular-directed therapy • Requires parameters characterizing tumor vasculature (Ktrans, IAUC) to be comparable between patients, scanners, institutions and over time

  4. Plans • Define phantom for quantitative DCE-MRI • Define generic DCE-MRI acquisition protocols • Plan and conduct phantom study to evaluate comparability of protocols across sites/platforms • Define procedure for routine phantom use • Develop simulated data set for algorithm testing • Plan and conduct multi-site test-retest study using phantom and generic protocol

  5. Progress (1) • Define phantom for quantitative DCE-MRI • Modified IRAT/ADNI phantom (July 2008)

  6. Progress (2) • Define generic DCE-MRI acquisition protocols • Generic protocols for 1.5 T (July 2008) • Dynamic • T1 • Ratio (RF sensitivity correction?) • Implemented on GE, Philips & Siemens scanners (September 2008)

  7. Progress (3) • Develop simulated data set for algorithm testing • Dynamic data (August 2008) • T1 data (October 2008)

  8. Progress (4) • Plan and conduct phantom study to evaluate protocol comparability across sites/platforms (anticipate mid-October 2008 for plan, target December 2008 for study completion) • Define procedure for routine phantom use (target January 2009) • Plan and conduct multi-site test-retest study using phantom and generic protocol (target 1Q09 for plan, 3Q09 for completion)

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