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Torsten Thunberg, F. Batelli & L.S. Stern

Torsten Thunberg, F. Batelli & L.S. Stern. The Reactants of. t he Krebs Cycle. By Emily MacDonald and Laura Le. Introduction. - (1906 – 1920) Thunberg tried to understand cellular respiration by testing how organic substances were oxidized animals tissue. ( eHow . 2009)

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Torsten Thunberg, F. Batelli & L.S. Stern

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  1. Torsten Thunberg,F. Batelli & L.S. Stern The Reactants of the Krebs Cycle By Emily MacDonald and Laura Le

  2. Introduction • - (1906 – 1920) Thunberg tried to understand cellular respiration by testing how organic substances were oxidized animals tissue. (eHow. 2009) • (1920) F. Batelli and L.S. Stern were interested in oxidative cell metabolism. They used enzymatic studies on catalase and fumarase. (eHow. 2009)

  3. Before the Experiment • Previous scientists Carl Cori and Gerry Cori investigated the conversion of nutrients into energy through anaerobic respiration. -The understanding of glycolysis was important due to the production of two pyruvate molecules that provided energy through ATP for further stages in cellular respiration. - Enzyme activity was used as a basic knowledge for their experiments It was understood that muscular activity requires ATP as energy.- F. Batelli and L.S. Based their studies off of Thunberg’s knowledge. • (Nelson, David L., & Cox, Michael M. 2005)

  4. The Experiment • Thunberg performed the first investigation by examining the oxidization of organic substances in isolated animal issues. He tested over 60 organic substances, mostly in muscle tissue. • He found that the combustion of nutrients is the repeated process of hydrogen ions separating with the help of enzymes. • F. Batelli and L.S. Stern used beef liver as their experimental investigation. They found that the enzyme Fumarase was essential for oxidation and reduction.- Studied and researched Catalase and Fumarase.(Akart, Konrad. 1996)

  5. - Thunberg characterized photosynthesis as an oxidation –reduction reaction in which CO2 is reduced and water is oxidized. - He also discovered oxidative degradation of foodstuff of animals. After the Experiment - F. Batelli and L.S. Stern concluded that minced animal tissues contained substances that transferred hydrogen atoms from specific intracellular organic acids. (eHow. 2009) - They were able to understand how the products of glycolysis were continued on to then become reactants of the Krebs Cycle. (Giora, Hons. 2009)

  6. References: - Akart, Konrad. Swiss Contributions to the Neurosciences. 1996.http://books.google.ca/books?id=bQfyTCULessC&pg=PA32&lpg=PA32&dq=F.+Batelli+and+L.S.+Stern+krebs+cycle&source=bl&ots=rHbz0AtJH0&sig=Tnjn5yO7B9ilm_rjl57G3Oll46o&hl=en&ei=aqPiTMerMsqWnwfV6pDyDw&sa=X&oi=book_result&ct=result&resnum=4&ved=0CDMQ6AEwAw#v=onepage&q&f=false - eHow. The History of the Krebs Cycle. 2009.www.ehow.com › Health › Diet & Nutrition › Nutrition - Giora, Hon. Philoscience. 2009. www.philoscience.unibe.ch/documents/textarchive/Nickelsen2009cfb.pdf - Krebs, HA. The Krebs Cycle Lecture. 1930.nobelprize.org/nobel_prizes/medicine/.../krebs-lecture.pd- Nelson, David L., & Cox, Michael M. Lehninger Principles of Biochemistry Fourth Edition. 2005.http://en.wikipedia.org/wiki/Cori_cycle

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