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Protein-Protein Interactions: Mapping the Unknown

Explore the world of protein-protein interactions and their crucial role in biological processes. Discover novel interactions using machine learning methods and unlock the potential of systems biology research.

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Protein-Protein Interactions: Mapping the Unknown

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  1. PROTEIN-PROTEIN INTERACTIONS Madhavi K. Ganapathiraju Associate Professor Department of Biomedical Informatics University of Pittsburgh madhavi@pitt.edu Faculty of Biomedical Informatics Training Program Intelligent Systems Program Joint CMU-Pitt Ph.D. Program in Comp Bio Language Technologies Institute (CMU) Genes to Function to Therapeutics Informatics and Engineering for Biomedicine@ University of Pittsburgh

  2. Protein-Protein Interactions Central to all biological processes and structural scaffolds The network is a medium for systems biology research But 90% of protein-protein interactions are unknown today ? ~22,500 protein-coding genes Human Interactome 200,000 to 600,000 PPIs protein-pairs ~250Million possible pairs Theme of Research in Madhavi’s Lab Discovery of protein-protein interactions from large data sourcesusing Machine Learning methods Results: 1000’s of Novel PPIs discovered Accurately

  3. Recent Interests Electronics and Communications Engg • Smart Lifestyle • IoTEnabled Sensors for Health • Stress Monitoring through Sensor Fusion

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