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با نام و یاد خدا

با نام و یاد خدا. Interferons. Type I( ,), Autocrine and paracrine Cause sequestration of lymphocytes Promote diff. naïve T cells Increase cytotoxicity of NK and CTLs Upregulate expression MHC-I Treatment of some tumors. Cells and Tissues of the immune system.

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با نام و یاد خدا

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  1. با نام و یاد خدا

  2. Interferons Type I(,), Autocrine and paracrine Cause sequestration of lymphocytes Promote diff. naïve T cells Increase cytotoxicity of NK and CTLs Upregulate expression MHC-I Treatment of some tumors

  3. Cells and Tissues of the immune system • The cells of the adaptive immune system are normally present: a)Circulating cells in the blood and lymph b)Anatomically defined collection in lymphoid organs c)Scattered cells in all tissues

  4. Lymphocytes Antigen presenting cells(APC) Effector cells

  5. Cells of the immune system (lymphocytes) • Lymphocytes are the only specific cells and are responsible for specificity and memory • They are 3 subsets ,different in functions and protein products but not in morphology 1-B cells 2- T cells(helper and cytotoxic) 3- Natural killer (NK) cells

  6. B lymphocyte development stem cell Pro B cells CD19,CD10, µ heavy chain rearrangement Pre B cells Pre antigen receptor expression immature B cells IgM BCR expression,independent of antigen and their encounter with it ,receptor editing,cell death,functional unresponsiveness Mature B cells

  7. B cell surface markers • B cell receptor(Ag recognition) • CD19 (B cell activation) • CD21or CR2 (B cell activation and EBV receptor) • CD25 (binds IL- 2) • CD27 (memory B cells ) • CD40 (B cell activation) • CD80 or B7(costimulator for T cell activation) • CD81 (B cell activation)

  8. T cell subpopulations T lymphocytes mature in the thymus *Mature T cells :Th and Tc,TR *T cells have CD4, CD8,TCR(αβ & ) ,CD28,CD40L,CD2,CTLA-4(memory T cells have IL-7 R) *T helper cells have 2 subsets :Th1 and Th2 are differentiate by cytokine pattern that they produce. *Th1=IFN- *Th2 =IL-4 , IL-5,IL-10, IL-13

  9. Clonal selection

  10. Effector cells • Activated Th cells • Cytolytic T cells • Plasma cells • Mononuclear phagocytes • Nk cells

  11. Phagocytosis

  12. NK cell activity

  13. Dendritic cells Coventional Dc Plasmacytoid Dc

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