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What is evolution ?. Change through time. Biological evolution Change in allele frequencies in populations. How evolution works:. Basic biological facts. 1) mutations introduce genetic variation. 2) some individuals survive and reproduce. 3) their genes get passed on.
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What is evolution? Change through time Biological evolution Change in allele frequencies in populations
How evolution works: Basic biological facts 1) mutations introduce genetic variation 2) some individuals survive and reproduce 3) their genes get passed on IF only some of the indv’s in the pop’n survive & reproduce and IF the indv’s that survive & reproduce are NOT representative of the starting pop’n THEN the 2 generations will differ Voila!! Genetic change in the population… evolution!
deleterious mutations X X survival & reproduction X high mutation rate survival & reproduction variation in HIV population X X X survival & reproduction X X some change in population more change in population population of HIV particles
Basic biological facts 1) mutations introduce genetic variation 2) some individuals survive and reproduce 3) their genes get passed on IF only some of the indv’s in the pop’n survive & reproduce and IF the indv’s that survive & reproduce are NOT representative of the starting pop’n THEN the 2 generations will differ How evolution works: DIFFERENCE in % of POP‘N with different genes
Basic biological facts 1) mutations introduce genetic variation 2) some individuals survive and reproduce 3) their genes get passed on WHY NOT?? IF only some of the indv’s in the pop’n survive & reproduce and IF the indv’s that survive & reproduce are NOT representative of the starting pop’n THEN the 2 generations will differ How evolution works: DIFFERENCE in % of POP‘N with different genes
reproduction AZT AZT X X most mutations are deleterious reproduction AZT AZT reproduction resistant HIV particles survive AZT reproduce & pass on their genes
Natural selection: 1) genetic variation * 2) some genes improve survival or reproduction 3) these genes get passed on INCREASE in % of POP‘N with beneficial genotype Whether a genotype is beneficial DEPENDS ON THE ENVIRONMENT Population becomes adapted to the environment because of change in gene frequency
Evolution is important to our lives • Food • artificial selection for better crops & livestock • pesticide resistance • Health • drug resistance • emerging diseases • Environment • invasive species • endangered species