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I nterreg- IPA Cross-border Cooperation Programme Romania-Serbia

I nterreg- IPA Cross-border Cooperation Programme Romania-Serbia. Male microchimerism in the human female brain where it comes from and what it does. Sanja Kalaba February 2019. Employment promotion and basic services strengthening for an inclusive growth. INTRODUCTION.

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I nterreg- IPA Cross-border Cooperation Programme Romania-Serbia

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  1. Interreg-IPA Cross-border Cooperation Programme Romania-Serbia Male microchimerism in the human female brain where it comes from and what it does SanjaKalaba February 2019 Employment promotion and basic services strengthening for an inclusive growth

  2. INTRODUCTION • Microchimerism- beneficial or adverse effects • Real-time quantitative PCR detects and quantifies male DNA in multiple brain regions of women • AD more prevalent in parous then in nulliparous • Higher number of pregnancies correlates with a younger age of AD onset

  3. Subjects and specimens • 26 deceased women without neurological disease and 33 women with AD • Age of death ranged from 32 to 101 • Age of AD onset in those who had it ranged between 64 and 93 years, 77 median • Frontal lobe, parietal lobe, temporal lobe, occipital lobe, cingulate gyrus, hippocampus, amygdala, caudate, putamen, globus pallidus, thalamus, medulla, pons, cerebellum and spinal cord

  4. STATISTICS • Association was reported as an odds ratio (OR) along with p value to indicate significance • Rate ratio - RR of 0.30 could be interpreted to say that the rate of Mc detection in subjects with AD was 70% lower than the rate of Mc detection in subjects without neurological disease

  5. RESULTS • Mc Prevalence and Concentration According to Brain Regions • Prevalence and Concentration of Male Mc in Human Brain: Women without Neurologic Disease or with AD • Prevalence and Concentration of Male Mc in Brain Regions Affected by AD

  6. The origin of male Mc in female brain is: • from pregnancy with a male fetus • from an abortion or a miscarriage • from a recognized or vanished male twin, an older male sibling • or through non-irradiated blood transfusion

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