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Core Facilities at UCSF and Beyond

Core Facilities at UCSF and Beyond. Teri Liegler, PhD Director ARI-UCSF Laboratory of Clinical Virology CFAR Virology Core Laboratory tliegler@sfgh.ucsf.edu. What is a core facility?. NIH Definition

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Core Facilities at UCSF and Beyond

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  1. Core Facilities at UCSF and Beyond Teri Liegler, PhD Director ARI-UCSF Laboratory of Clinical Virology CFAR Virology Core Laboratory tliegler@sfgh.ucsf.edu

  2. What is a core facility? • NIH Definition • “A centralized, shared resource that provides scientific investigators with access to instruments; technologies; services; cellular, animal or human study support; and expert consultation” • >80 at UCSF and affiliated institutions

  3. Core Facility Mission at UCSF • Service: Provides cutting-edge and state-of-the-art technologies and expertise in an efficient operation • Education: Provides explicit training in the proper application of technology and analysis of the data produced • R & D: Provides an environment for technology and application development, broadening the use and applicability of research tools globally and enhancing local discovery

  4. Why and when to use a core? • Expand your research scope and capacity • Expedite progress by using services already up and running • Save money by ‘renting’ rather than ‘buying’ • Gain critical insight by consultingwith experts throughout the study • Especially at the inception stage

  5. What are the CFAR cores? • Clinical/Population Science • Jeff Martin MD, MPH, Steve Deeks MD • Immunology • Jeff Milush PhD • Pharmacology • Fran Aweeka PharmD • Specimen Banking • John Greenspan BDS, PhD, Yvonne DeSouza • Virology • Teri Liegler, PhD

  6. Why are CFAR cores special? • Cores are a business, but not really… • Mandate to support & enhance institutional research • Restricted on how we can make and spend money • Must be cost neutral, can’t show profit • CFAR funds 5 cores to promote ‘Value Added’ services • Education, training and mentoring • State of the art equipment • New assay development • “Conception − to − Publication” support for projects

  7. Managing core use can be daunting! Specimens Nucleic Acid Extraction and Modification Bioinformatics HIV Sequencing Genomic SNP Analysis

  8. Core Synergy at Work! CFAR Clin and Specimen Core = CFAR Immunology Core Manuscript CFAR Virology Core UCSF Genomics Core

  9. How do I find the right Core?

  10. Gladstone Cores

  11. But can I afford using a core? • You get what you pay for! • Quality, accountability and experience • Sometimes, time is $$ • May partially cover costs for new development work • Consult with core director on study design, hypothesis, sample selection and services early in process • Institutional supplements

  12. Funding Opportunities for Core Use • UCSF Resource Allocation Program (RAP) • Career Development • International • Multidisciplinary • Pilots • Technology • For CFAR sponsored, encourage use of CFAR Cores • Gilead Sciences Research Scholars Program in HIV • amfAR Institute for HIV Cure Research

  13. Pilot program up to $4,000 • Remove barriers for 1st time core users • Expand the scope and breadth of core users • Spark new offerings and collaborations with cores • Easy app, rapid turnaround, 6 month duration

  14. Thank You! Questions? tliegler@sfgh.ucsf.edu 206-8929

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