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Categorization of Substances on the DSL: Operational Approach

Categorization of Substances on the DSL: Operational Approach. DOMESTIC SUBSTANCES LIST. ENVIRONMENT CANADA. HEALTH CANADA. Persistent OR Bioaccumulative According to the Regulations. Greatest Potential for Human Exposure. HEALTH CANADA. ENVIRONMENT CANADA.

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Categorization of Substances on the DSL: Operational Approach

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  1. Categorization of Substances on the DSL: Operational Approach DOMESTIC SUBSTANCES LIST ENVIRONMENT CANADA HEALTH CANADA Persistent OR Bioaccumulative According to the Regulations Greatest Potential for Human Exposure HEALTH CANADA ENVIRONMENT CANADA Persistent OR Bioaccumulative and “Inherently Toxic” to Humans Persistent OR Bioaccumulative and “Inherently Toxic” to non-Human Organisms SCREENING LEVEL RISK ASSESSMENT

  2. Outcome of Screening Level Risk Assessments SCREENING LEVEL RISK ASSESSMENTS No further action under this program Toxic (Possible VE) PSL

  3. Definitions

  4. Guiding Principles of Water Quality Guidelines: • Protect all life stages of all species • All components of ecosystem should be considered • Recommended guideline is a single maximum value not to be exceeded. This value is based on a long-term no-effect concentration. • Unless otherwise specified, a guideline refers to the total concentration in an unfiltered sample

  5. Threshold Effect Level: TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment Threshold Effect Level: TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment

  6. Threshold Effect Level: TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment Threshold Effect Level: TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment

  7. Threshold Effect Level: TEL = (1 x 0.0015) = 0.387 mg/kg dry sediment

  8. Guidelines for the Protection of Wildlife TDI = (LOED x NOED)0.5 x Safety Factor TDI = Tolerable Daily Intake (mg/kg.day) LOED = Lowest Observed Effects Dose (mg/kg.day) NOED = No Observed Effects Dose (mg/kg.day) -1

  9. TRG = TDI x BW x AF / Food Ingestion Rate BW = Body Weight (kg) Food Ingestion Rate (kg/day) TRG = Tissue Residue Guideline (mg/kg.day) AF = Appointment Factor

  10. Probable Effect Level: PEL = (20 x 0.02) = 0.632 mg/kg dry sediment

  11. No Observed Effect Level (NOEL): NOEL = 0.5 x TEL = 0.5 x 0.387 = 0.194 mg/kg dry

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