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Women’s Health Center of Excellence Research at Ochsner

Discover the latest research studies conducted at the Women's Health Center of Excellence at Ochsner. These studies cover various topics, such as chronic hypertension in pregnancy, prophylactic negative pressure wound therapy, induction versus expectant management, and more.

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Women’s Health Center of Excellence Research at Ochsner

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  1. Women’s Health Center of ExcellenceResearch at Ochsner June 2, 2017

  2. CHAPChronic Hypertension in Pregnancy • NIH funded study: 4700 women, 25 hospitals, 5 years • Research question: To treat or not treat mild CHTN in pregnancy; conflicting evidence • Subjects randomized (1:1) to: • Treatment: maintain BP <140/90 using labetalol and/or nifedipine ER • Standard: no treatment unless BP increases to ≥160/105 • Pragmatic design- similar to routine care • Followed through 6 weeks postpartum

  3. Prevena-C Multicenter Trial Prophylactic Negative Pressure Wound Therapy in Obese Women at Cesarean: a Multicenter Randomized Trial • Large NIH funded study- 4 sites, 2850 subjects total • Objective: Assess effectiveness, safety, and cost-effectiveness of prophylactic negative pressure wound therapy in reducing rate of surgical site infections after cesareans in obese women • Includes both planned and unplanned c/s • Patients randomized 1:1 to either: • Prevena wound vacuum device • Standard bandage dressing

  4. Maternal-Fetal Medicine Units (MFMU) Network • National Institute of Child Health and Human Development (NICHD) created Network in 1986 • Current network comprised of 14 university based clinical centers and a data coordinating center • Ochsner is sub-site to UAB • Designed to conduct perinatal studies to improve maternal and fetal outcome with emphasis on randomized controlled trials • Current/starting MFMU Network trials: • ARRIVE • Prospect

  5. ARRIVEA Randomized Trial of Induction Versus Expectant Management • Research question: Does elective induction of labor in nulliparous women at 39 weeks improve perinatal outcome compared with expectant management? • Design: randomized, controlled study 6000 women- 2 arms • Elective induction 39w 0d to 39w 4d • Expectant management until 40w 5d+ • Followed through 6 weeks postpartum

  6. PROSPECTA Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation with a Short Cervix • Primary Hypothesis- In women with twin gestation with short cervical length, risk of preterm birth < 35 weeks is reduced with: • Arabin cervical pessary • Vaginal progesterone • Design: • 3 groups- pessary, progesterone, placebo drug • Randomized after ultrasound shows short cervix • Drug/device until 35 weeks • Followed through outcome

  7. Blood Draws Studies- Industry Sponsored • Sera PrognosticsTREETOP study • Validation of PreTRM test to predict preterm birth • Development of new tests to predict preterm birth • Population: Healthy pregnant women <22 weeks • Chart review through delivery and postpartum • Progenity, Inc. PRO-100 • Evaluate screening method for characterizing chromosomal defects, deletions, aberrations in maternal blood • Population: Pregnant women at risk for abnormality with CVS or amniocentesis scheduled • Chart review through delivery and postpartum

  8. Women’s Health Biobank • Samples for both in-house and commercial • Control patients- urine • Pregnant patients- various time points in pregnancy and delivery • Blood • Amniotic fluid • Cord amniotic fluid • Placenta • Urine • Various treatments- frozen, formalin, RNAlater

  9. Problem Pregnancy Exosomes • Enroll • 50 pregnant women recently diagnosed GDM, preeclampsia, or FGR- 2nd or 3rd trimester • 50 matched controls • Collect 12ml blood sample (EDTA) & send to UQ for exosome analysis • after consent • upon admission for delivery • morning after delivery • Follow outcomes

  10. PPROM A Randomized Double-Blind Trial Comparing the Impact of 1 vs 2 Courses of Anetnatal Steroids on Neonatal Outcome in Patients with Prelabor Premature Rupture of Membranes • Compare 1 vs 2 doses of antenatal corticosteroids in women with expectantly managed PPROM • <33weeks GA • 2nd blinded course given 7+ days after 1st

  11. AbbVie Elagolix • Elagolix- novel, orally administered gonadotropin-releasing hormone antagonist (GnRH Antagonist) • Alters level of pituitary GnRH suppression so, titrating circulating estrogen levels are achieved • May provide relief from pain associated with endometriosis and uterine fibroids • Studied in multiple clinical trials- 2 at Ochsner

  12. Contact information- at Baptist • Chris Servay- x73039 and Kate Garvey x-35967 • Sherri Longo, MD- CHAP, ARRIVE, PROSPECT, Prevena-C, TREETOP, Progenity-100, exosomes, EGGO, PPROM studies • Nicolle Crovetto- x35878 Biobank • Donnalee Trapani- x72864 Elagolix studies

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