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Insulin Pdx4

Insulin Pdx4. A. WT. KO. Figure S1. A. Lactate levels (mice). B. NADPH levels (livers). P < 0.03. P < 0.009. Figure S2. Expression levels of glycolytic genes in KO MEFs. A. Expression levels of TCA cycle genes in KO MEFs. B. Figure S3. Expression levels of Pentose Phosphate

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Insulin Pdx4

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  1. Insulin Pdx4 A WT KO Figure S1

  2. A Lactate levels (mice) B NADPH levels (livers) P< 0.03 P< 0.009 Figure S2

  3. Expression levels of glycolytic genes in KO MEFs A Expression levels of TCA cycle genes in KO MEFs B Figure S3

  4. Expression levels of Pentose Phosphate Pathway genes (MEFs) Expression levels of Gluconeogenesis genes (MEFs) C D E Expression levels of Gluconeogenesis genes (livers) Figure S3

  5. A HIF1α target genes expression (MCF7) B HIF1α target genes expression (MCF7) ** ** ** ** ** * * * ** C HRE-Luciferase Assay D HIF1α mRNA levels in skeletal muscles P< 0.001 P< 0.001 P< 0.09 P< 0.01 Figure S4

  6. A NBDG-glucose uptake ** ** * ** B HIF1α target genes expression in WT treated mice C HIF1α target genes expression in KO treated mice ** ** Figure S5

  7. Endogenous WWOX physically interacts with endogenous HIF1α B Normoxia (+MG 132) Hypoxia IP: Anti-HIFα Anti-HIFα Anti-IgG Anti-IgG Anti-wwox Anti-wwox Lysis Lysis HIFα-OH WWOX interacts physically with HIF1α via its first WW domain A Hypoxia MG132 Input HIFα GST SDR GST WW1+2 GST SDR GST WW1+2 Control GST WW1 GST WW1 GST WW2 Control GST WW2 LAMIN WWOX HIFα HSP90 GST Figure S6 Hypoxia Pull down MG132 GST SDR GST WW1+2 GST SDR GST WW1+2 Control GST WW1 GST WW2 Control GST WW1 GST WW2 HIFα GST

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