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Clarence Chan Forrest Lab University of Michigan Project 1 Electrical Engineering PhD Candidate

Thrust Area 1: Nanomanufacturing (Glue) Thrust Area Leader: Stephen Forrest. Clarence Chan Forrest Lab University of Michigan Project 1 Electrical Engineering PhD Candidate. Nanosystems Engineering Research Center for Directed Multiscale

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Clarence Chan Forrest Lab University of Michigan Project 1 Electrical Engineering PhD Candidate

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  1. Thrust Area 1:Nanomanufacturing (Glue) Thrust Area Leader: Stephen Forrest Clarence Chan Forrest Lab University of Michigan Project 1 Electrical Engineering PhD Candidate Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision National Science Foundation: EEC-1647837

  2. Overview • Clarence Chan is an Electrical Engineering PhD student and a member of the Optoelectronic Components and Materials group at the University of Michigan. His work would be applied to TA1 of the CELL-MET ERC. • Question: Can we translate the technologies and materials developed by the semiconductor industry for applications in scaling and parallel processing for tissue engineering purposes? • Contents of talk: • Introduction • Technology and Challenges • Applications and Expectations Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  3. Introduction: Thermal Evaporation • Vacuum Thermal Evaporation (VTE) • Physical vapor deposition technique • Operates under high vacuum (10-7 torr) • Evaporation from resistive heating • Issues • Material coats everything • Material utilization is low Source Mask – Metal or Si Substrate Angstrom VTE system from the OCM deposition lab Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  4. Introduction: Organic Vapor Jet Printing • Organic Vapor Jet Printing (OVJP) • Physical vapor deposition utilizing inert carrier gas • Operates under vacuum (10-4 torr) • Evaporation from resistive heating (higher temperature) • Improvements • Directional write patterning • High material utilization Image courtesy: Gregory J. McGraw Figure from Shteinet al, Advanced Materials, 2004 Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  5. Technology • OVJP is used for direct writing organic material • The most fundamental application is in display technology • OLEDs used in displays for phones and TVs can be produced this way • The resolution required for high pixel density is enabled via micro-nozzles • Ideal for parallel and scaled production Image courtesy: Gregory J. McGraw Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  6. Challenges • The key challenges for OVJP are: • Line of sight (LOS) • High temperature deposition • Resolution is limited to micron scale • Nozzle/Substrate registration • Vacuum process • Key problem to solve: • How to integrate this scalable direct write technology with other ERC processing techniques such as Atomic Calligraphy and Nanoscribe Nozzle Source Source + gas flow H Mask – Metal or Si Substrate Substrate Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  7. Three-Plane Diagram Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  8. Application • OVJP allows writing of patterned organic small molecules on surface • Organic small molecules can be used as a negative for anti-cell adhesion coatings • Cells can interface with the surface via protein which can selectively adsorb against organic negative patterns Image courtesy: Gregory J. McGraw OCM Group Logo Figure from Chen et al, Science, 1997 Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  9. Expectations • Generating focal adhesion sites for cells allows: • Mechanistic studies of cell to environment interfacing • Insight on how to engineer suitable tissue models • Fundamental processing should be scalable and can integrate into a roll-to-roll (R2R) process • Samples can then be produced with high throughput to accelerate testing (i.e. assays) OCM Lab R2R System. Image courtesy: Angstrom Engineering Figure from Qu et al, Applied Physics Letters, 2018. Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET National Science Foundation: EEC-1647837

  10. Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision National Science Foundation: EEC-1647837

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