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Grignard Reaction

Reaction Handled. Grignard Reaction. Key features : Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium. Key features : Strong base such as KO t Bu, NaH, n -BuLi handled. Boron trifluoride etherate.

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Grignard Reaction

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  1. Reaction Handled Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as KOtBu, NaH, n-BuLi handled. Boron trifluoride etherate Key features: Moisture sensitive catalyst BF3:Et2O handled .

  2. Reaction Handled Suzuki Coupling Key features: Handling of air sensitive reagents, Aromatic C-C bond formation. Negishi Coupling Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. Gomberg Reaction Key features: Handling of diazonium salt. Aromatic C-C bond formation.

  3. Reaction Handled Ritter Reaction Key features: Displacement of tertiary alcohol group with amido group. Kolbe Carboxylation Key features: Handling of high pressure reaction. Vilsmeier-Haack Reaction Key features: POCl3 handling. Typical formylation reaction.

  4. Reaction Handled Birch Reduction Key features: Handling of pyrophoric metals. Aromatic reduction. Borane Reduction Key features: Pyrophoric BDMS handled. Baeyer-Villiger Oxidation Key features: Handling of reactive chemical, like peracid, Peroxide, etc.

  5. Reaction Handled Hofmann Rearrangement Key features: Hypobromite handled. Synthesis of amine from ketone. Reformatsky Reaction Key features: Handling of sensitive organometallic reagent Skraup Synthesis Key features: Oxidation using H2SO4 and Nitrobenzene.

  6. Reaction Handled Chiral Separation Key features: Separation of racemic pure compound. Asymmetric Hydrogenation Key features: Synthesis of optically pure compound. Asymmetric Reduction Key features: Handeled pyrophoric reagents. High ee achieved.

  7. Reaction Handled Transesterification Key features: Acid/ base catalyzed transesterification. Click Chemistry Key features: One-pot triazole chemistry. Thiophene Chemistry Key features: Handeled n-BuLi, sulfur dioxide gas.

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