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Supplementary Figure 3A. hu_PPARG prom 3 G A C C G C C G C T T G G G G A C C G G G G G A C C G T T C A G C - G A G G G G C G C G C T - - - T 46 ch_PPARG prom 3 G A C C G C C G C G T G G G G A C C G G G G G A C C G T T C A G C - G A G G G G C G C G C T - - - T 46
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Supplementary Figure 3A hu_PPARG prom 3 G A C C G C C G C T T G G G G A C C G G G G G A C C G T T C A G C - G A G G G G C G C G C T - - - T 46 ch_PPARG prom 3 G A C C G C C G C G T G G G G A C C G G G G G A C C G T T C A G C - G A G G G G C G C G C T - - - T 46 rh_PPARG prom 3 - - - - - - C G C G C G G G G A C C G C G G G A C C G T T C A G C - G A G G G G A G C G C T - - - T 40 mo_Pparg prom 3 G C C A G G T C T C C - - - - - - - - - A G A A C T A C C G C G T T G G G G A C C G C A T T G T G C 41 ra_Pparg prom 3 G C C A G G T C T C C G C A C G G T C C A G A A C T C C C G C G - - G G A G G C C G C A T T G T G T 48 hu_PPARG prom 3 G T A G C - T G G C C A G G C C C T G T G C C C T G A C G C G T T G T G C T G G C C C T A C G C C C 95 ch_PPARG prom 3 G T A G C - T G G C C A G G C C C T G T G C C C T G A C G C G T T G T G C T G G C C C T A C G C C C 95 rh_PPARG prom 3 G G G G C - T G G C C A G G C C C C G T G C C C G G A C G C G T T G T T C T G G C C C T G C G C C C 89 mo_Pparg prom 3 G G A T C C T G G T G A C A G A T T T - A G A G A G G G G C T C G C C A G C A G C C A C C G G T C G 90 ra_Pparg prom 3 G G A T C - T G G T G A C A G T T T T C A G A G A G G G G C T C G C C A G T A G C C A C C G G G T A 97 hu_PPARG prom 3 G G C G G A G G G G C T G G G G A C G G G - G A C T G G G T G C C T C C G T G C C T C C G C G G A T 144 ch_PPARG prom 3 G G C G G A G G G G CTG G G G A C G G G - G A C T G G G T G C C T C C G T G C C T C C G C G G A T 144 rh_PPARG prom 3 G G CG GA G G G A C T G G G G A C G G G - G A C T G G G T T C C T C C G T G C C T C G G C G G A T 138 mo_Pparg prom 3 C C C T G A G G C T C T A G G G G T C G G A G G G T G G G G A G G A G G A T G C G C C C G T G - A T 139 ra_Pparg prom 3 C C C C G A G G C GC T GG G G G T G G - - - - - - G G G G A G G A G G G T G C G C C G G T G - A T 140 hu_PPARG prom 3 G G A G C G C G C A G C C A G G A C C C C C A G C C G C A C C C C G - G G G G G C T G G A A A G G C 193 ch_PPARG prom 3 G G A G C G C G C A G C C T G G A C C C C C A G C C G C A C C C C G T G G G G G C T G G A A A G G C 194 rh_PPARG prom 3 G G A G C G C G C A G C C T G G A C C C C C A G C C G C A C C G C G - G G G G G C T G G A A A A G C 187 mo_Pparg prom 3 C A C G G A G G C G A T T T G G C C C A C G G C CC C C - - - T G C C C G G G G C T C A C C A G G T 186 ra_Pparg prom 3 C G T C T A A G C A A C T T G G C C C G G G G C T C C C G CCC G C C C G G G G C T C G C C A G G T 190 hu_PPARG prom 3 G A A G T C G C T G C T T T G T G G G C T C C T G C A A G T G C C A G G C G C T G A C C A C T C C T 243 ch_PPARG prom 3 G A A G T C G C T G C T T T G T G G G C T C C T G C A C G T G C C A G G C G C T G A C C A C T C C T 244 rh_PPARG prom 3 G A A G T C G C T G C G T T G T G G G C T C C T G C A C G T G C C A G G C G C T G A C C A C T C C T 237 mo_Pparg prom 3 G T G A G G A A A G C G G G G T C A - C T G T C G C C A A G G C C C C G C C C C G C C A G T G C C C 235 ra_Pparg prom 3 G T G A G G A A A A T G G G G T C A - C T G T C G C C A A G G C C C C G C C C C A C C A G T G C C C 239 hu_PPARG prom 3 C C T G G G A G C C T A A C T G A G G G G G G T A G A G G C A G C A G A G G T T A A C A G A A A T C 293 ch_PPARG prom 3 C C T G G G A G C C T A A C T G A G G G G G G T A G A G G C A G C A G A G G T T A A C A G A A A T C 294 rh_PPARG prom 3 C T T G G G A G C C T A A C T G A G G G G G G T A G A G G C A G C A G A A G T T A A C A G A A A T C 287 mo_Pparg prom 3 C T C T T C A A T C T A A G C A G G G G G C G A G C A C A G G G C C C G G C T C A C G G G A G T A G 285 ra_Pparg prom 3 C T C T T C A G C C T A G G A A G G G G G C G A G C A C A G G G C A G G G C T A A C T G G A G T A G 289 hu_PPARG prom 3 T C A G G T C C C T - - - - - - T G G T G G A A GG T G G G T G T G T A G T C G T - G G T A C T T T 336 ch_PPARG prom 3 T C A G G T C C C T - - - - - - T G G T G G A A GG T G G G T G T G T A G T C G T - G G T A C T T T 337 rh_PPARG prom 3 T C A G G T C C C T C G T T G T T G G T G G A A GG T G G G T G T G T A G T C G T - G G T A C T T T 336 mo_Pparg prom 3 G C A G C C C T C G T G C T G G G G G C G G A A GG T G G G T G T G T G G C T C C C G G T G C T T T 335 ra_Pparg prom 3 G C A G C C C T C G T G G T G G G G G T G G A A GG T G G G T G T G T G G C T C C - G G T G C T T T 338 hu_PPARG prom 3 A C G C C T C G G T G T T T A G G G A G G A G C C T A A G G T AA G G A G T C A G A A A C G G G G A 386 ch_PPARG prom 3 A C G C C T C G G T G T T T A G G G A G G A G C C T A A G G T AA G G A G T C A G A A A C G G G G A 387 rh_PPARG prom 3 A C G C C T C G G T G T T T A G G G A G G A G C T T A A G G T AA G G A G T C A G A A A C G G G G A 386 mo_Pparg prom 3 A T G G C T T G G - G A T T G G G G A G G A G C C T A A G G T G A G G A G G C A G A A A C T G G G A 384 ra_Pparg prom 3 A T G G C T T G G - G A G T G G G G A G G A G C C T A A G G T G A G G A G G C A G A A A C T G G G A 387 hu_PPARG prom 3 G T A A C C G A G C T G C G G C T T T T A T A T A A G G T C A G T G - G T A G G T A A G G A A G G G 435 ch_PPARG prom 3 G T A A C C G A G C T G C G G C T T T T A T A T A A G G T C A G T G - G T A G G T A A G G A A G G G 436 rh_PPARG prom 3 G T A A C C G A G C T G C G G C T T T T A T A T A A G G T C A G T G - G T A G G T A A G G A A G G G 435 mo_Pparg prom 3 G T A G C C T G G - - G C T G C T T T T A T A T A A G G G A C G C G A G G A G G T C A A G A A G G G 432 ra_Pparg prom 3 G T A G C C T G G - - G C T G C T T T T A T A T A A G G G A C T C G A G G A G G T C A A G A A G G G 435 hu_PPARG prom 3 G C C T T A A C C T C T G C T G G T G A C C A G A A G C C T G C A T T T C T G C A T T C T G C T T A 485 ch_PPARG prom 3 G C C T T T A C C T C C G C T G G T G A C C A G A A G G C T G C A T T T C T G C A T T C T G C T T A 486 rh_PPARG prom 3 G C C T T T A C C T C T G C T G G T G A C A A G A A G G C T G C A T T T C T G C A T T C T G C T T A 485 mo_Pparg prom 3 G C C T G G A C C T C T G C T G G G G A T C T G A A G G C T G C A G C G C T A A A T T C T T C T T A 482 ra_Pparg prom 3 G C C T G G A C C T C T G C T G G T G A T C A G A A G G C T G C A G C G C T A A A T T C A T C T T A 485 hu_PPARG prom 3 A T T C C C T T T C C T T A G 500 ch_PPARG prom 3 A T T C C C T T T C C T T A G 501 rh_PPARG prom 3 A T T C C C T T T C C T T A G 500 mo_Pparg prom 3 A C T C C C A T T G A G T A G 497 ra_Pparg prom 3 A C T C C C A T T G A G T A G 500 RREB1 site B RREB1 site A C/EBP beta/delta Sp1 AP-1 deltaEF1/TCF8
AP-1 Consensus (+): NTGASTCAG PPARG prom 3 sequence: AGGAGTCAG i C/EBP beta consensus (+): TKDNGMAAK PPARG prom 3 sequence: TGGTGGAAG ii Sp1 Consensus (+): GRGGCRGGGW PPARG prom 3 sequence: GAAGGTGGGT iii deltaEF1 (TCF8) consensus (-): C ACCTTAG PPARG prom 3 sequence: T/C ACCTTAG iv RREB-1 consensus sequence: CCCCAAAC A/C A/C CCCC PPARG prom 3 site (A) (+): CCCCAGCCGCACCC PPARG prom 3 site (B) (-): CCCCAGCCCCTCCG v Supplementary Figure 3B