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Ulcer Wars!

Ulcer Wars!. Compiled by Mrs J Wright, Durban Girls’ High School,2006. Slide 1. The Problem – an Ulcer!. Definition : ulcer n. an open sore on an external or internal surface. Ulcers – found in the stomach lining, and though to be caused

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Ulcer Wars!

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  1. Ulcer Wars! Compiled by Mrs J Wright, Durban Girls’ High School,2006

  2. Slide 1 The Problem – an Ulcer! Definition : ulcer n. an open sore on an external or internal surface

  3. Ulcers – found in the stomach lining, and though to be caused by stressful living. Slide 2

  4. Slide 3 Using an endoscope to view an ulcer and a tissue sample then taken to be analysed View of an ulcer in the stomach

  5. Slide 4 Dr Robin Warren - pathologist Team work The curious observation made by Dr Robin Warren in the samples given to him to analyse. These observations were investigated by Dr Marshall.

  6. Slide 5 In the laboratory. Team work to produce a culture of H. pylori!

  7. Slide 6 Dr Barry Marshall – 1981, Australia

  8. Slide 7 Culture of Helicobacter pylori A sample was taken and viewed under the Electron Microscope After months of trials and failures, an unplanned long weekend in the incubator produced a result!

  9. Slide 8 The villian! A Helicobacter pylori C B

  10. Slide 9 Removal of H. pylori and healing of the ulcer? Scanning E.M of H.pylori on the stomach walls.

  11. Slide 10 How the ulcer is formed H. pylori causes excess production of HCl by cells of the stomach lining. The stomach is trying to kill the bacterium. The excess acid removes the mucus layer and the stomach cells are then attacked, resulting in an ulcer. Acid inhibitors such as Tagamet now usually prescribed for relief but they have to be taken continually.

  12. Slide 11 Test kits for Helicobactera pylori

  13. Slide 12 Drinking the urea solution: Blowing out into a test tube.

  14. Slide 13 H. pylori breath test – gas chromatograph reads results.

  15. Slide 14 Ammonia identified in exhaled air. This is due to H. pylori conversion of Urea into ammonia. How the test works.

  16. Slide 15 Results that provide further proof of the connection between H pylori and ulcers. H pylori removed within 2 weeks after taking antibiotics!

  17. Slide16 Communicating their findings Book: The Ease & Difficulty of a New Discovery. Author: Robin Warren

  18. Slide17 Acceptance at last!

  19. Slide 18

  20. Slide 19 Nobel prize announced - 2005 From initial discovery in 1981 until acknowledgment by the scientific community in 2005!

  21. Further findings… Slide 20 Now thought to be responsible for stomach cancer and heart disease. Remove H pylori and reduce the risk! H. pylori in the blood Spread by poverty and down through the families! Simple prevention!

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