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Guide to the Organ Compartments in the General Physiologically Based Pharmacokinetic Model

Guide to the Organ Compartments in the General Physiologically Based Pharmacokinetic Model. September 16, 2010 BioE 310 Fall Semester Professor Andreas A. Linninger Department of Bioengineering University of Illinois, Chicago, IL.

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Guide to the Organ Compartments in the General Physiologically Based Pharmacokinetic Model

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  1. Guide to the Organ Compartments in the General Physiologically Based Pharmacokinetic Model September 16, 2010 BioE 310 Fall Semester Professor Andreas A. Linninger Department of Bioengineering University of Illinois, Chicago, IL

  2. Scalable Physiologically Based Pharmacokinetic Models (PBPK) aBrown, 1994. bForsyth, 1968. cDelp, 1998.

  3. Key to Artery, Organ and Vein Location = Organ/Capillaries = Artery/arterioles = Vein/venules = Non-resistive connection

  4. 1. 2. Zoom 3. No trifurcation 4. 5. 8. 6. 9. 10. 7. 11. 12. 13. 14.

  5. Organ Guide • Left forelimb • Right forelimb • Brain • Blood flows back into heart • Blood flows out of heart to body • Stomach and intestines • Hepatic artery • Liver • Left kidney • Right kidney • Left hindlimb • Right hindlimb • Tail • Lumped “other”

  6. Organ Constituents • “Fore/hindlimbs & tail” include: • Muscle, skin, fat, bone • Forelimbs: 3/8 of the combined flows • Tail: 1/8 of combined flows • Hindlimbs: ½ combined flows • “Other”, if possible includes: • Heart, lung, adrenal, reproductive, salivary, thyroid, and parathyroid, and any other provided or unaccounted flows • “Brain”: • Brain and spinal cord • “Stomach and Intestines”, if possible, includes : • Esophagus, stomach, duodenum, jejunum, ileum, cecum, colon, rectum, pancreas, mesentery, and spleen

  7. Pressure Specifications for Each Segment

  8. Generating α Values (Resistances) The Hagen–Poiseuille Equation: or, where: (and F = Q)

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