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BIOSYNTHESIS OF AMINO ACIDS

BIOCHEMISTRY

mprasadnaidu
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BIOSYNTHESIS OF AMINO ACIDS

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  1. Biosynthesis of Amino Acids M.Prasad Naidu MSc Medical Biochemistry, Ph.D,.

  2. Overview

  3. Overview (cont)

  4. Biosynthetic Families Metabolic Precursors Amino Acids a-ketoglutarate Glutamate Glutamine Proline Arginine 3-Phophoglycerate Serine Glycine Cysteine

  5. Biosynthetic Families (cont) Metabolic Precursors Amino Acids Oxaloacetate Aspartate, Asparagine Methionine, Threonine, Lysine Pyruvate Alanine, Valine, Leucine Isoleucine

  6. Biosynthetic Families (cont) Metabolic Precursors Amino Acids Phosphoenolpyruvate Tryptophan and erythrose 4-phosphate Phenlyalanine Tyrosine Ribose 5-phophate Histidine

  7. a-Ketoglutarate Family

  8. a-Ketoglutamate to glutamate/glutamine Glutamate + NH4+ + ATP Glutamine synthetase Glutamine + ADP + Pi + H+ a-Ketoglutamate + glutamine + NADPH + H+ 2 glutamate + NADP+ Glutamate synthase

  9. a-Ketoglutamate to glutamate/glutamine Net Reaction: a-Ketoglutarate + NH4+ + NADPH + ATP L-glutamate + NADP+ + ADP + Pi

  10. a-Ketoglutarate Family

  11. Synthesis of Proline

  12. Synthesis of Proline

  13. Synthesis of Arginine

  14. Synthesis of Arginine

  15. 3-Phosphoglycerate Family

  16. Synthesis of Serine and Glycine

  17. Synthesis of Cysteine

  18. Oxoloacetate Family

  19. Synthesis of Aspartate and Asparagine Aspartate Oxaloacetate Transamination from glutamate Amidation with Glutamine donating NH4+ Asparagine

  20. Synthesis of Lysine, Methionine, and Threonine • See handout

  21. Pyruvate Family

  22. Synthesis of Alanine Alanine Pyruvate Transamination from glutamate

  23. Synthesis of Isoleucine, Valine,and Leucine • See handout

  24. Phosphoenolpyruvate and erythrose 4-phosphate Family

  25. Synthesis of Chorismate

  26. Synthesis of Tryptophan

  27. Synthesis of Tyrosine and Phenylalanine

  28. Synthesis of Tyrosine and Phenylalanine (cont)

  29. Biosynthesis of Histidine • See handout

  30. Possible Test Questions • Provide the 6 metabolic precursors and the amino acids which they lead to. • Duplicate the Amino Acid Synthesis Overview Flow Chart. Expand the sections need to show the synthesis of Glutamate, Glutamine, Proline, Arginine, Serine, Cysteine, Glycine, and starting from Chorismate Tryptophan, Tyrosine and Phenylalanine. (40 points!!)

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