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BONE TUMORS

BONE TUMORS. Bone tumors. Bone tumors are classified into: Primary bone tumors Secondary bone tumors ( Metastasis) Most are classified according to the normal cell of origin and apparent pattern of differentiation. Bone tumors. Bone-forming tumors Cartilage-forming tumors

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BONE TUMORS

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  1. BONE TUMORS

  2. Bone tumors • Bone tumors are classified into: • Primary bone tumors • Secondary bone tumors ( Metastasis) • Most are classified according to the normal cell of origin and apparent pattern of differentiation

  3. Bone tumors • Bone-forming tumors • Cartilage-forming tumors • Miscellaneous tumors • Hematopoietic tumors • Fibrous tumors

  4. Bone-Forming tumors Osteoma Osteoid osteoma and osteoblastoma Osteosarcoma Cartilage-Forming tumors Chondroma (Enchondroma) Osteochondroma Chondrosarcoma Miscellaneous tumors Ewing’s sarcoma Giant cell tumor of bone Primary Bone Tumors

  5. Bone-Forming Tumors

  6. Osteoma • Osteoma are benign lesions of bone that in many cases represent developmental aberrations or reactive growths rather than true neoplasms. • Site; • Age; • Gross: • Histology:

  7. Osteosarcoma • Osteosarcoma is a bone-producing malignant mesenchymal tumor .

  8. Osteosarcoma • Incidence: • Age: • Sex: • Site :

  9. OsteosarcomaDistribution

  10. Osteosarcoma Radiograph

  11. Osteosarcoma Gross features

  12. Bone-Forming tumors;

  13. Cartilage -Forming Tumors

  14. Osteochondroma Morphology • Osteochondromas are mushroom shaped and range in size from 1 to 20 cm. • The outer layer of the head of the osteochondroma is composed of benign hyaline cartilage varying in thickness • Newly formed bone forms the inner portion of the head and stalk, with the stalk cortex merging with the cortex of the host bone.

  15. Osteochondroma (exostosis)Gross

  16. Osteochondroma (exostosis)Microscopic The cap is benign hyaline cartilage, resembling disorganized growth plate undergoing endochondral ossification. Newly formed bone forms the inner portion of the head and stalk

  17. Chondrosarcoma • Chondrosarcomas comprise a variety of tumors sharing the ability to produce neoplastic cartilage

  18. ChondrosarcomaGross features • SITE; • pelvis, • shoulder, • ribs. • rarely involve the distal extremities.

  19. ChondrosarcomaMicroscopic • These tumors are composed of lobules of cartilage with anaplastic chondrocytes in the lacunae and with focal enchondral ossification and calcification.

  20. Cartilage-forming Tumors;

  21. Giant Cell Tumor • This is a neoplasm that contains large numbers of osteoclast like giant cells admixed with mononuclear cells. • These tumors are slightly more common in females.

  22. Giant Cell TumorGross

  23. Giant Cell TumorMicroscopic

  24. METASTATIC BONE TUMORS • Metastatic tumors are the most common malignant tumor of bone. • Pathways of spread: • Origin: • The radiologic appearance of metastases

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