Visible light is electromagnetic radiation that can be seen by the human eye. The wavelengths of visible light spans fro

2. Wavelengthandfrequencyarethetwomostimportantproperties of lightwaves. The behavior of Electromagnetic (EM) radiation depends on its wavelength. Higher frequencies have shorter wavelengths, and lower frequencies have longer wavelengths.

3. Visible light is electromagnetic radiation that can be seen by the human eye. The wavelengths of visible light spans from about 380 nm to 740 nm.

4. Our body has some natural protections against light ; • Eyebrows, eyelashes • Eye movements • Pupillary miosis (constriction of the pupil to two millimeters or less)

5. UV light is divided into three wave ranges. The sun emits ultraviolet radiation in the UVA, UVB, and UVC bands. UVAmeasures 380-315 nm, UVB extends from 314–280 nm and UVC is between 279-200 nm. • Blue light’s spectrum is dominated by energy with a wavelength of 400-500 nm. • The Cornea absorbs UVB and UVC, and most UVC raysare absorbed by the ozone layer and does not reach to the earth. Light in the range of 315-400 nm is absorbed by our natural lens so the light of these wavelengths may not reach the retina. Our natural lens has 3-HYDROXYKYNURENINE (3-OHKYN) and the oxidative polimerization of this material filters out light. CORNEA LENS

6. AlconAcrysof Natural400-500 nm The Filtration Ranges VSY Biotechnology Acriva UD BB 400-480 nm Hoya ISert Yellow 400-440 nm B&L Softport 400-440 nm

7. ACRIVA UD BB MATERIAL • Acriva UD BB possesses similarities to our natural lens’ chromophore structure. • This structure is derived from the natural structure of 3-HydroxyKynurenine. Natural human lens structure Acriva UD BB • The chromophore is shown in red. • Concentration percentage is 0.02%

8. Other IOL’s yellow chromophore structure • Do not contain any natural structures, only synthetic material. • Structure: N-2- (-3-(2methylphenylazo )-4-hydroxyphenyl) ethylmethacrylamide. It is a synthetic dye that is covalently bound to the polymer matrix and is intended to give a visible light transmission spectrum to the lens that resembles an old human liquid crystalline lens • Chromophore concentration is 0.04%

9. CONTRAST SENSITIVITY OTHER IOLs • Have a higherchromophoreconcentration (includes a 0.04% colorgradient). Thiscreates a darkyellowintraocular lens but decreasesthecontrastsensitivity of thepatient. • What is the reason for a higher chromophore concentration? • The main reason is not to provide good contrast sensitivity or better visual acuity • The only goal is to avoid glistening !

10. OTHER IOLs • Contrast sensitivity • İs low.

11. Acriva UD BB • Acriva UD BB contains a 0.02% yellow polymerized chromophore. • AcrivaUD BB does not haveany risk of glisteningandso it doesn’tneedtofilterbluelight at upperwavelengths. AcrivaUD BB onlyfilterslightbetween 400-480 nm, which is the optimum filtration, andthusprovidesbettercontrastsensitivityandcolorperception.

12. Acriva UD BB • Contrast sensitivity is • better than other IOLs.

13. Circadian rhtym: The body’s 24-hour cycle Scotopic vision: Vision under low light conditions Photopic vision: Vision under high light conditions

14. CIRCADIAN RHYTHM OTHER IOLs Filter blue light up through 500 nm. There is some clinical research which shows that filtering blue light can cause circadian rhytm disorders, especially if the IOL filters too much light in the blue range of wavelengths. Patients have expressed complaints about sleeplessness and depression after being implanted with these IOLs.

15. Acriva UD BB Filters blue light at an optimum range of 400-480 nm. This amount of filtration prevents the risk of circadian rhythm disorders and depression.

16. SCOTOPIC VISION Filtering blue light up through 500nm causes poor night vision.

17. Acriva UD BB Optimum filtration range provides better night vision quality.

18. AcrivaUD BB MODELS MONOFOCAL MODELS MULTIFOCAL MODELS TORIC MODELS

19. TORIC IOLS

20. CUSTOM-MADE WIDE PARAMETERS EASY CUSTOM ORDER

21. MULTIFOCAL MODELS MONOFOCAL MODELS Acriva UD T- UDM 611 Acriva UD Reviol T- MFM 611

25. PARAMETERS WHICH WE WANT AT TORIC ORDER FORMS - Keratometric results ( Diopter or millimetric): • K1 and K2 • Flat axis • Steep axis - IOL Spherical Power (From -25.00 D to +45.00 D, 0.50D increments) - Surgically-Induced Astigmatism - Incision Location • Advanced Calculation for Lenstar Biometry Users • ACD ( True Anterior Chamber Depth , The length between the lens and endothelium) • Lens Thickness

26. All Acriva UD Toric intraocular lenses are custom-produced. • Approximation method is not used – lenses are made to order. • IOLs are delivered in just 21 days.