1 / 12

NA or other

NA or other. +. 5-HT. Enk. +. +. +. NANC. 5HT 3. 5HT 4. -. +. ACh. DA. -. D2. Enk. +. -. WATER EXCRETION. 5HT 1or2. . Proximal Contraction. Distal Relaxation. ACh. -. ,. -. PERISTALTIC REFLEX. Water Excretion. NA or other. ACh. ACh. +. +. X. -. Motility.

myersr
Download Presentation

NA or other

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NA or other + 5-HT Enk + + + NANC 5HT3 5HT4 - + ACh DA - D2 Enk + - WATEREXCRETION 5HT1or2  ProximalContraction DistalRelaxation ACh - , - PERISTALTIC REFLEX

  2. Water Excretion NA orother ACh ACh + + X - Motility

  3. Don’t forget hormone actions esp. motilin, somatostatin ACh + Motility

  4. ACh DA - D2 +

  5. X ACh METOCLOPRAMIDE DA - D2 +

  6. NANC 5HT3 ACh 5HT4 - + ACh + 5-HT ProximalContraction DistalRelaxation + + PERISTALTIC REFLEX

  7. ACh 5HT4 + ACh + CISAPRIDE TEGASEROD(5HT4 agonists)

  8. ONDANSETRONALOSETRON(5HT3 antagonists) X NANC 5HT3 - ACh + 5-HT + INCREASED CONTRACTION BUT DECREASED MOTILITY!

  9. ACh Enk + - , -

  10. - NA or other 5HT1or2 + Enk  5-HT + ACh Enk + + inhibition of 5-HT mediating segmentation (not shown) - , -

  11. NA or other ACh + - 5HT1or2 +  5-HT DIPHENOXYLATE LOPERAMIDE ,

  12. - NA or other + 5HT1or2 5-HT Enk  + + + NANC 5HT3 ACh 5HT4 - + ACh - , - DA - D2 Enk + ALVIMOPAN and METHYLNALTREXONEare opioid receptor antagonists that increase motility and increase secretion The “SETRONS”are 5Ht3antagonist s that inhibit peristalsis CISAPRIDE and TEGASEROD are5Ht4 agonist s that increase motility METOCLOPRAMIDE is a DA antagonis thatacts as cholinomimeticsto increase motility DIPHENOXYLATE & LOPERAMIDE areopioids that decrease motilityand reduce secretion

More Related