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Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

Kristian Andvord’s break-through observation. Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60. The “Koch Phenomenon”. A primary infection leads to a delayed response and has often a mild and self-limited course

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Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

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  1. Kristian Andvord’s break-through observation Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60

  2. The “Koch Phenomenon” A primary infection leads to a delayed response and has often a mild and self-limited course A reinfection results commonly in a rapid response with tissue necrosis Drawings: Koch R. Mittheilungen aus dem Kaiserlichen Gesundheitsamte 1884;2:1-88. Phenomenon: Koch R. Dtsch Med Wochenschr 1891;17:101-2.

  3. Andvord Canetti Re-infection Morbidity / mortality Remaining live bacilli Birth cohort Primary infection Cross-sectional A B Age Time / age Koch BMRC BCG Trial Progressive Re-infection Abortive Tissue destruction BCG protection Primary infection C D Time Time

  4. Effect of Environmental Mycobacteria: Blocking and Masking Hypothesis Andersen P, et al. Nature Rev 2005;3:656-62

  5. …and another research question: If an individual is not protected by BCG, is tuberculosis more severe in this individual?

  6. Operating Characteristics of IGRAs Pai M, et al. Expert Rev Mal Diagn 2006;6:413-22

  7. Thank you for your attention and patience

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