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MEDICAL COMPLICATIONS OF ALCOHOL MISUSE. CIRRHOSIS. Presented by Dr. Glynn Jones to Clinical Officers at Lewanika Hospital, Mongu, Zambia (Via Skype) Date: June 7, 2013. OVERVIEW CIRRHOSIS. Definition Clinical Manifestation Management of Cirrhosis & Complications. Definition - What is it?.
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MEDICAL COMPLICATIONS OF ALCOHOL MISUSE CIRRHOSIS Presented by Dr. Glynn Jones to Clinical Officers at Lewanika Hospital, Mongu, Zambia (Via Skype) Date: June 7, 2013
OVERVIEW CIRRHOSIS • Definition • Clinical Manifestation • Management of Cirrhosis & Complications
Definition - What is it? • Late stage of progressive hepatic fibrosis • It is irreversible in its advanced stages • It is potentially reversible in its early stages • Patients with cirrhosis are susceptible to a variety of complications and their life expectancy is markedly reduced
Clinical Manifestations • Physical findings • A coincidental finding during surgery, radiological or laboratory investigation • May present with decompensated cirrhosis • Esophageal varices with hemorrhage • Ascites • Spontaneous bacterial peritonitis • Hepatic encephalopathy
Following slides demonstrate physical findings associated with liver disease
Diagnosis of Ascites and determination of cause • 1500 cc of fluid collection in abdomen before being able to detect on physical exam • Dullness to percussion in flank region • Ultrasound is gold standard for diagnosis
Diagnostic Paracentesis • Left lower quadrant 14g angiocath • Cell count • Albumin • SAAG > 11g/l • 98% sensitivity for diagnosis of portal hypertension • Cell count > 300 cells/ ml leukocytes indicative of spontaneous bacterial peritonitis
Tap fluid once to make diagnosis • Low salt diet 2-4g / day • Diuretics: • Lasix 40 mg • Aldactone 100 mg • And titrate upwards to effect • Monitor weight • and renal function
Hepatic Encephalopathy • Triggered by alcohol and sepsis • Treatment • Lactulose: orally or rectally
Conclusion • Alcoholic liver disease is common and preventable • Complications can be managed and add quality of life to the patient