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Recent key research accomplishments:

Recent key research accomplishments:. Polysaccharide Immunity Section Refined specificity of pneumococcal polysaccharide ELISA by use of both C PS and heterologous type (type 22F) polysaccharide preadsorption Developed a new general purpose high yield (> 70 %) conjugation method.

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Recent key research accomplishments:

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  1. Recent key research accomplishments: • Polysaccharide Immunity Section • Refined specificity of pneumococcal polysaccharide ELISA by use of both C PS and heterologous type (type 22F) polysaccharide preadsorption • Developed a new general purpose high yield (> 70 %) conjugation method

  2. Recent key research accomplishment: Cellular Immunity Section Identified a Polysaccharide interaction affecting activity of toll like receptors (TLRs)

  3. Recent key research accomplishments: • Pathogenic Neisseria Section • Showed that O acetyl groups on the meningococcal group A polysaccharide are critical for induction of bactericidal antibodies • Developed a sensitive gonococcal genetic porin (Por) typing system to investigate Por specific immunity to gonorrhea

  4. Recent key research accomplishments: • Lipopolysaccharide Section • Defined a new gene, lgtH, in the biosynthesis of meningococcal lipooligosaccharide • Found that sialylation of the terminal galactose of meningococcal LOS requires at least a trisaccharide moiety

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