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Role of Chemotherapy in the Current Treatment Paradigm for Men With CRPC

Role of Chemotherapy in the Current Treatment Paradigm for Men With CRPC. CRPC How do you decide who gets chemotherapy these days?. Who Should Get Chemotherapy? Patients with disease that is rapidly progressing, which may be less sensitive to androgen blockade.

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Role of Chemotherapy in the Current Treatment Paradigm for Men With CRPC

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  1. Role of Chemotherapy in the Current Treatment Paradigm for Men With CRPC

  2. CRPCHow do you decide who gets chemotherapy these days?

  3. Who Should Get Chemotherapy?Patients with disease that is rapidly progressing, which may be less sensitive to androgen blockade.

  4. Second-line ChemotherapyAdverse Effects Issues

  5. ChemotherapyAvoiding Undue Toxicity

  6. ChemotherapyFailure of Adding Targeted Agents

  7. Targeted Agents + ChemotherapyPotential Scheduling Problems

  8. Targeted Agents + ChemotherapyBetter preclinical data are needed to design the next round of trials!

  9. Retreatment With ChemotherapyIt is feasible in a selected group of patients who responded initially.

  10. Manipulating Hormone TherapyIs it possible to safely make the disease more chemo-sensitive?

  11. Radium-223Where does it fit in relation to chemotherapy?

  12. Ra-223 Before Chemotherapy or in Combination With Other Agents?Because Ra-223 does not induce bone marrow toxicity, this possibility needs to be tested in clinical trials.

  13. Should Chemotherapy Be Moved Earlier in the Course of Disease?Currently, chemotherapy should not be given outside the metastatic castration-resistant setting!

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