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Law of Bergonie’ and Tribondeau

Law of Bergonie’ and Tribondeau. Law of Bergonie’ and Tribondeau. It was developed in 1906 by two French radiobiologist, Bergonie’ and Tribondeau It offers a prediction about the relative sensitivity of two different types of cells or tissues to radiation. Law of Bergonie’ and Tribondeau.

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Law of Bergonie’ and Tribondeau

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  1. Law of Bergonie’ and Tribondeau

  2. Law of Bergonie’ and Tribondeau • It was developed in 1906 by two French radiobiologist, Bergonie’ and Tribondeau • It offers a prediction about the relative sensitivity of two different types of cells or tissues to radiation

  3. Law of Bergonie’ and Tribondeau • It states that the radiosensitivity of cell is directly proportional to their reproductive activity and inversely proportional to their degree of differentiation. • Cells most active in reproducing themselves and cells not fully mature will be most harmed by radiation. • The more mature and specialized in performing functions as cell is, the less sensitive it is to radiation.

  4. More radiosensitive cells • Cells that have a high division rate • Cells that have a high metabolic rate • Cells that are of a non-specialized type • Cells that are well nourished

  5. Sensitivity – Cell Cycle Phase • Cells are most sensitive to radiation during mitosis (M phase) and RNA synthesis (G2 phase) • Less sensitive during the preparatory period for DNA synthesis (G1 phase) • Least sensitive during DNA synthesis (S phase) • During mitosis (M), the metaphase is the most sensitive

  6. Radioresistant cells • Bone • Liver • Kidney • Cartilage • Muscle • Nervous tissue

  7. Radiosensitive cells • Germinal cells • Lymphoid tissues • basal cells • Hematopoietic tissues • Epithelium of the GI tract

  8. Gonads are very radiosensitive Females Temporally sterility 1.5 Gy (150 rad) Permanent sterility 5 Gy (500 rad) Males Temporally sterility 2.5 Gy (250 rad) Permanent sterility 6 Gy (600 rad)

  9. Pregnancy and minors • Children could be expected to be more radiosensitive than adults • fetuses more radiosensitive than children and embryos even more in the first weeks of pregnancy when organs are forming

  10. Radiosensitivity of various cell types Radiosensitivity Cell type Low nerve cell muscle cells Intermediate osteoblast,endothelial cells,fibroblast,spermatids spermatogonia, lymphocytes, stem cells, High intestinal mucosa cells and erythroblast

  11. Questions • The law of Bergonie and tribondeau states that the radiosensitivity of cell is directly proportional to their reproductive activity and inversely proportional to their degree of differentiation. - True 2. Those cells with a low metabolic rate are more radiosensitive. - False 3. Cells are more sensitive during meiosis phase. - False 4. Gonads are very radiosensitive cells -True 4. List four of the radioresistant cells. -bone, liver, kidneys, muscles

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