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1. Protein Folding and Misfolding
4. COMPARATIVE GENOMICS
1-DIMENSIONAL SEQUENCE DNA
REGULATORY REGIONS
SNPs and HAPLOTYPES
PEPTIDES/PROTEINS
ASSEMBLY
3-DIMENSIONAL/ STRUCTURE PROTEINS
GEOMETRY
LOGIC/ CHEMISTRY EXPRESSION/ RNA/REGULATION
NETWORKS
5. Pairwise Structure Alignment Structure of protein plays an instrumental role in determining its function
Two proteins with similar 3D structure are more likely to have the same finction than two without similar structure
Pair wise protein structure alignment tools have been used to study relationships between proteins
STRUCTAL, VAST, DALI are among most popular such tools
6. SELF-AVOIDING WALK
7. Statistical Mechanics:184 self-avoiding walks through a 3x3 grid
8. Statistical Mechanics:156 self-avoiding walks through a 2x1x1 lattice
10. Alberto Caprarra, Bob Carr, Giuseppe Lancia, Brian Walenz, Sorin Istrail
11. CONTACT MAPS
12. CONTACT MAPS
13. CONTACT MAPS
14. CONTACT MAPS
15. ASILOMAR: Protein Folding --A Paradigm-Shift
16. FOLD RECOGNITION