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台灣地區多囊性卵巢症候群內分泌特性與濾泡液蛋白質表現之探討

台灣地區多囊性卵巢症候群內分泌特性與濾泡液蛋白質表現之探討. 多囊性卵巢症候群(Polycystic ovary syndrome，簡稱PCOS)，為一種女性相當常見的內分泌異常的疾病，也是女性不孕的主要原因之一。多囊性卵巢症候群除了會造成不孕外，也會導致許多其他症狀，並會提高某些慢性疾病的罹病風險。一般而言，PCOS患者會有多囊性卵巢、月經異常、雄性素與胰島素過高等現象，因其症狀複雜，故而診療的困難度也隨之增加。

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台灣地區多囊性卵巢症候群內分泌特性與濾泡液蛋白質表現之探討

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  1. 台灣地區多囊性卵巢症候群內分泌特性與濾泡液蛋白質表現之探討台灣地區多囊性卵巢症候群內分泌特性與濾泡液蛋白質表現之探討 多囊性卵巢症候群(Polycystic ovary syndrome，簡稱PCOS)，為一種女性相當常見的內分泌異常的疾病，也是女性不孕的主要原因之一。多囊性卵巢症候群除了會造成不孕外，也會導致許多其他症狀，並會提高某些慢性疾病的罹病風險。一般而言，PCOS患者會有多囊性卵巢、月經異常、雄性素與胰島素過高等現象，因其症狀複雜，故而診療的困難度也隨之增加。 本研究中，我們與台安醫院生殖醫學中心合作，針對約320例病人之內分泌相關資訊進行資料分析，並利用蛋白質二維電泳分析濾泡液中之蛋白質表現，以試圖瞭解台灣地區PCOS族群與國外之差異性。 資料分析結果可以發現台灣與國外PCOS族群之BMI分布不同，台灣PCOS肥胖之比例較國外的報告低，且BMI值也較國外族群來的小。由分析中也發現台灣PCOS族群之BMI與LH皆高於控制組，且PCOS組顯現出雄性素過高與胰島素過高等現象。本研究中另外也利用Receiver operating characteristic curve(ROC)分析，找出幾個常見指標之建議切點以便提供臨床在診斷上的參考。 在蛋白質二維電泳部分，我們發現在控制組與PCOS組間可以觀察到有差異之訊號存在，但目前仍無法得知其為單純之個體差異或是PCOS所造成之表現差異。在電泳結果中我們觀察到Alpha-1 Antitrypsin、Vitamin D-binding protein與Fibrinogen Gamma-A chain之表現量皆相當穩定，因此之後或許可以將這些蛋白列為內部控制組(internal control)作參考，進一步比較濾泡液中蛋白組成之變化，以便於以卵巢微環境之變化瞭解PCOS可能之致病機制。

  2. Study of endocrine and follicular fluid protein expression of PCOS patients in Taiwan • From 1997 to 2000, 160 blood samples(dog 114；cat 2；mouse 12；pigeon 17；goat 3；bat 1；wild boars 3 and flying squirrel 8 ) and 79 stool samples (dog 20；mouse 12；pigeon 30；guinea pig 3；goat 2；wild boars 4 and flying squirrel 8 ) were periodically collected from the animals lived with and hunted by the aboriginal tribes people of 5 villages in Taiwan (Nan Au village in Yi Lan county：Dung Au, Nan Au,Bi Hou,Jin Yue,Wu Ta, Jin Yang and Au Hau；Jin Feng village in Tai Dung county：Jeng Shing,Jia Lan,Shin Shing,Bin Mau and Li Chiou；Hai Duan village in Tai Tung：Hai Duan,Kan Ding,Jia Na Wu Lu,Li Dau,Guang Yuan,Jin Ping andChu Lai；Da Jen village in Tai Tung：Tai Ban,Tu Ban,Shin Hua,An Shuo,Nan Tian, and Sen Yung；Da Wu village in Tai Tung：Shang Wu,Da Wu,Da Ju,Nan Shing, and Da Niau； coast mountain of Hua Lian county). The dog lived with people showed that the infection rates of Toxoplasma gondii, Dirofilaria immitis ,Hepatazoon canis, Ancylostoma spp. ,Toxocara canis and Trichuris vulpis are 21.9%(25/114), 6.1%(7/114), 1.8%(2/114), 35.0% (7/20), 20.0%(4/20), and 5.0%(1/20), respectively. Meanwhile, the Haemoproteus spp. of pigeon is 41.2%(7/17) and the Babesia spp. of mouse is 41.7%(5/12). About the mouse stood, it showed that the infection rates of Ancylostoma spp., Strongyloides ratti and Diphyllobothrium spp. are 16.7%(2/12), 25.0%(3/12) , and25.0%(3/12) , respectively. Meanwhile the multi-infection rates of Strongyloides ratti and Diphyllobothrium spp. are 8.3% (1/12), and 25.0% (3/12). The Strongyloides papillosus of goat is 50.0%(1/2). The Strongyloides ratti of guinea pig is 33.3% (1/3). There were only 2 blood samples of wild boars and flying squirrel. The infection rates of both Toxoplasma gondii and Suifilaris suis of wild boars are 33.3%(1/3). The total parasitic infection rate is 75.0% and 100% in stool samples. The wild boars results showed that all the infection rates are 50.0%(2/4) to Ascaris suum, Trichuris suis, Strongyloides ransomi and Hyostrongylus rubidus, except the Ascarops strongylina is 25.0 %(1/4). The investigation of flying squirrel showed the infection rates of Trichuris spp., Syphacia spp., Coccidia spp., Strongyloides ratti and Nippostrongylus muris are 25.0%(2/8), 87.5%(7/8), 75.0%(6/8), 50.0%(4/8), and 37.8%(3/8), respectively. The 2, 3 and 4 multi- infection of wild boars are 25.0%(1/4). The 2, 3 and 4 multi- infection of flying squirrel are 50.0%(4/8), 25.0%(2/8), and 25.0%(2/8), receptively. In this investigation, the data is accumulated progressively and matched with the current study location and the main purpose is for establishing the animal''s parasitic data of aboriginal tribes'' area in Taiwan and link to Geography Information System. Then the infectious disease, public health, epidemiology and epidemic situation of human and animal in aboriginal tribes could be monitored and controlled instantly and the hygiene education of the tribes could be improved and the parasite disease induced by other disease could also be reduced.

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