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Erythropoietin and hemodialysis (anemia)

Erythropoietin and hemodialysis (anemia). M106 65 陳嬿雅 104 陳佩儀. E rythro po ietin(EPO). A glycoprotein - a hematopoietic growth factor of red blood cells (erythrocytes) in mammals A cytokine for erythrocyte precursors (hematopoietin or hemopoietin)

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Erythropoietin and hemodialysis (anemia)

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  1. Erythropoietin and hemodialysis (anemia) M106 65 陳嬿雅 104 陳佩儀

  2. Erythropoietin(EPO) • A glycoprotein - a hematopoietic growth factor of red blood cells (erythrocytes) in mammals • A cytokinefor erythrocyte precursors(hematopoietin or hemopoietin) - produced in the kidney and liver

  3. Functional EPO • Also : • playing a significant role in the brain's response to neuronal injury • involvement in the process of wound healing

  4. Erythropoietin receptor • (EpoR) • a hematopoietic cytokine receptor specifically present on erythroid progenitor cells Tyrosine kinase receptor

  5. Recombinant human EPO • a genetic engineering product • identical to natural human • The first clinical use for anemia(FDA) • chronic renal failure in predialysis or dialysis patients • zidovudine (Retrovir) therapy in patients infected HIV • patients receiving chemotherapy in nonmyeloid malignancies

  6. Hemodialysis • removing waste products from the blood • renal replacement therapies • Hemodialysis can be an outpatient or inpatient therapy • Procedure

  7. Hemodialysis • Principle • Diffusion • Convection • Classification • Intermittent dialysis • Continue dialysis • Functions of hemodialysis

  8. Indications & Complications • Indications • Acute & chronic renal failure • Drug poisoning • Refractory edema • Metabolic Disturbances • Complications • Low blood pressure • Fatigue • Nausea • Iron-deficiency Anemia : blood loss from the technique of hemodialysis

  9. Anemia • Having less than the normal number of RBC or less than the quantity of hemoglobin. • Male< 13.0g/dl • Female< 12.0g/dl • Anemia in hemodialysical patient • Insufficiency or resistance of EPO • Blood loss • Insufficiency of iron, vit. C, Vit B6, Vit. B12 and folic acid

  10. Treatments • An adequate hemodialysis dose • Monitoring the portion of blood iron regularly and its transfer efficiency • Adequate complements of EPOs • Appropriate nutrition intakes • Doing some aerobic exercises (ex: swimming) • Avoiding from blood loss • Controlling infections in advance

  11. References • http://www.cari.org.au/CKD_Prevent_List_Published/Erythropoietin.pdf • http://www.hdcn.com/symp/05anna/02/pet1/pet1.htm • http://www.uptodate.com/contents/erythropoietin-for-the-anemia-of-chronic-kidney-disease-in-hemodialysis-patients?source=see_link • http://www.mountnittany.org/wellness-library/healthsheets/documents?ID=3890 • http://pubs.acs.org/cen/coverstory/83/8325/8325erythropoietin.html • http://en.wikipedia.org/wiki/Hemodialysis • http://www.epogen.com/professional/erythrokinetics/erythrokinetics.html • http://www.nature.com/nrc/journal/v5/n7/fig_tab/nrc1648_F2.html • http://www.cancernetwork.com/cancer-management-11/chapter40/article/10165/1406535

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