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Build up of Amyloid in Alzheimer’s Disease (arrow)

Build up of Amyloid in Alzheimer’s Disease (arrow). Removal of brain amyloid in an AD patient following active immunization (top) Persistence of brain amyloid in a non- immunized patient (bottom). Amyloid (red) in non-immunized mouse (top) is removed in mice

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Build up of Amyloid in Alzheimer’s Disease (arrow)

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  1. Build up of Amyloid in Alzheimer’s Disease (arrow)

  2. Removal of brain amyloid in an AD patient following active immunization (top) Persistence of brain amyloid in a non- immunized patient (bottom) Amyloid (red) in non-immunized mouse (top) is removed in mice after immunization (bottom)

  3. Amyloid Fibril Nerve Cell Medications may promote removal of amyloid by interfering with clumping of amyloid fibrils

  4. -amyloid precursor protein Extracellular space TM Cytoplasm A peptide COOH NH2 -secretase -secretase New medications may prevent deposits of amyloid by modulating specific enzymes alpha-secretase Abeta-42 Abeta-40 Abeta-42 Selkoe DJ et al. JAMA. 2000;283:1615-1617.

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