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STAPHYLOCOCCUS

STAPHYLOCOCCUS. Eko Budi Koendhori. Taksonomi. Famili : Micrococcaceae Genus : Staphylococcus : Micrococcus : Stomatococcus : Planococcus Ada 35 spesies tp hanya 3 yg penting S. aureus ( coagulase pos) S. epidermidis S. saprophyticus. Dinding Sel Bakteri Gram + dan -.

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STAPHYLOCOCCUS

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  1. STAPHYLOCOCCUS Eko Budi Koendhori

  2. Taksonomi • Famili : Micrococcaceae • Genus: Staphylococcus : Micrococcus : Stomatococcus : Planococcus • Ada 35 spesiestphanya 3 ygpenting • S. aureus (coagulase pos) • S. epidermidis • S. saprophyticus

  3. DindingSelBakteri Gram + dan -

  4. Morfologi • Kokus • Diameter ±1 µm • Gram positif • Non motil • Sporaneg • Reaksiempedudanoptokhinneg (resisten) • Pd media cair : tunggal, diplokokus, tetrad, rantai • Aerob/mikroaerob • Tumbuhcepat pd 37⁰ C • 20 ⁰ C pigmenterlihatbaik • Koloni • Bulat, halusmenonjol, berkilau, pigmen pos • S.aureus : kuningemas • S.epidermidis : putih • Hemolisabervariasi • Pd media kaldudananaerobpigmenneg Morfologi Biakan

  5. SifatPertumbuhan • Tumbuh pd hampirsemua media (nutrien, media agar darahdll) • Meragikarbohidrat asamlaktat • Katalasepos • Tahanterhadapkekeringan, panas(50 ⁰ C, 30 mnt, Na Cl 9% • Pekaterhadapheksaklorofen 3 %

  6. Resistensi • -Lactamase(plasmid): PnclnG, ampicillin, ricarcillin, piperacillin • MecAgene (chromosome): Nafcillin, methicillindanoxacillin • Vancomycin-intermediate S. aureus (VISA) suscp MIC ≤ 2μg/ml; intermdt ≤ 4-8 μg/ml ; resist ≥ 16 μg/ml. • Vancomycin-resistant S. aureus (VRSA) : vanA • Plasmid-mediated resist to tetracycline, erythromycin, aminoglycoside • Tolerance

  7. Struktur Antigen • Peptidoglikan: polysaccharide polymer, exoskeleton, rusakolehasamkuatataulisosim, memicuproduksiIL-1 , opsonisasiAB, chemoattractantthdsel PMN, aktivasikomplemen, miripendotoxin • AsamTeikhoat : polimergliserolatauribitolfosfatantigenik. • Prot A : mengikatFcdariIgG • Kapsul: menghambatfagositosis

  8. Enzym& Toxin • Katalase • Koagulase (oksalat & sitratdi plasma) danclumpungfactor (fibrin) • Hyaluronidase, staphylokinase • Exotoxin (α (hemolysin),β (sphingomyelisin),δ(merusakmembranbilogis), (hemolysin)) • Leukocidin(merusaklekosit) • Exfoliative toxin (epidermolytictx) • Toxic shock syndrome toxin-1 • Enterotoxin

  9. Staphylococcus aureus

  10. Identifikasi • 20-50% populasiS.aureus (+) dihidung • β hemolytic pada agar darahdomba • MengfermentasiMannitol • Golden pigmented (aureus)- sering • Koagulase-positif

  11. Penyakit • pneumonia • osteomyelitis • septic arthritis • bacteremia • endocarditis • abscesses/boils • Infeksikulit lain

  12. Keracunanmakanan • Bukaninfeksi • kontaminasimakananolehS.aureus • tumbuh • enterotoxin • Timbuldansembuhnyaterjadidalamhitungan jam

  13. Gejalakeracunanmakanan • muntah • nausea • diare • Nyeriperut

  14. Toxic shock syndrome • Demam • Ruammerah • Deskuamasi • Muntah • Diare • Toxic shock toxin • menyebar • Organism • lokal

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