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WHAT IS LDH?

WHAT IS LDH?. Enzyme found in a variety of tissues Different isoforms Role is inter-conversion of pyruvate & lactate Is also a marker of tissue damage. CORI CYCLE. www.wikipedia.org. ROLE OF LDH: A NEW VIEW. Brooks et al. 1999. IMPLICATIONS FOR ENDURANCE.

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WHAT IS LDH?

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  1. WHAT IS LDH? • Enzyme found in a variety of tissues • Different isoforms • Role is inter-conversion of pyruvate & lactate • Is also a marker of tissue damage

  2. CORI CYCLE www.wikipedia.org

  3. ROLE OF LDH: A NEW VIEW Brooks et al. 1999

  4. IMPLICATIONS FOR ENDURANCE • Brooks suggests interval training – use O2 to “burn” lactate in the mitochondria: • Build more mitochondria • Increase lactate transporter molecules (MCT-1)

  5. SUMMATION • Role of LDH in maintaining muscle pH • Importance of high-intensity training forLDH production

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