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Remote memory

Remote memory. Hippocampus Neocortex Retrograde amnesia Nongraded amnesia (Spatial memory tasks) Multiple trace theory. methods. Physical studies Pharmacological studies Genetic lesion studies Cellular and temporal precise Optogenetics ( Opsin Genes).

nathaniel-cervantes
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Remote memory

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  1. Remote memory Hippocampus Neocortex Retrograde amnesia Nongraded amnesia (Spatial memory tasks) Multiple trace theory

  2. methods Physical studies Pharmacological studies Genetic lesion studies Cellular and temporal precise Optogenetics (Opsin Genes)

  3. Specific Optogenetic Inhibition (OGI)of Excitatory Neurons in Dorsal CA1 Reduces Neuronal Activity

  4. A temporally precise, stable and reversible manner

  5. CA1 OGIBlocks Contextual Fear Acquisition and Retrirval A real-time involvement of CA1 excitatory cells, during acquisition and recall

  6. No difference in exploration

  7. Acquisition and expression of fear denpend on the amygdala

  8. CA1 OGIReversibly Interferes with Remote Fear Memory Recall

  9. Ongoing involvement, default activator of the memory trace

  10. Disturb only recent but not remote OPI limits expression of compensatory mechanisms

  11. Precise but Not Prolonged CA1 OGI Blocks Remote Contextual Fear Recall

  12. Interrupted in the midst of a behavioral session Hippocampus participate in remote memory trace maintenance

  13. Brain-wide Mapping of Circuit Activity Controlled by the Hippocampus during Remote Recall

  14. CA1 recruiting brain-wide fear memory activity Increased activity compensating for hippocampal inactivation

  15. OGI of Anterior Cingulate Cortex (ACC) Inhibits Remote but Not Recent Contextual Memory

  16. Olfactory bulbs (OB), no effect

  17. Point not clear This result at once demonstrates that a sudden drop in a major source of synaptic input to cortex need not nonspecifically influence recall (without ruling out a contribution from such an effect) and also points to the specificity of ACC in remote memory (consistent with prior work).

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